Heart Rhythm
Volume 6, Issue 6 , Pages 752-759 , June 2009

Left cardiac sympathetic denervation for the treatment of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia using video-assisted thoracic surgery

  • Christopher A. Collura, MD

      Affiliations

    • Department of Pediatrics/Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Jonathan N. Johnson, MD

      Affiliations

    • Department of Pediatrics/Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Christopher Moir, MD

      Affiliations

    • Department of Surgery/Division of Pediatric Surgery, Mayo Clinic, Rochester, Minnesota
    • ,
  • Michael J. Ackerman, MD, PhD

      Affiliations

    • Department of Pediatrics/Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota
    • Department of Medicine/Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
    • Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Michael J. Ackerman, Long QT Syndrome Clinic and the Mayo Clinic Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Guggenheim 501, 200 First Street SW, Rochester, Minnesota 55905

  • Image Result

    Anatomy of left cardiac sympathetic denervation (LCSD). A: An anatomical drawing of the left cardiac sympathetic chain after exposure through the pleura that is resected during VATS-LCSD. The stellate

    Anatomy of left cardiac sympathetic denervation (LCSD). A: An anatomical drawing of the left cardiac sympathetic chain after exposure through the pleura that is resected during VATS-LCSD. The stellate ganglion is located under the superior edge of the incision. The dashed line indicates the resection of the lower half of the left stellate ganglion occurring just above the major lower branches. B and C: Videoscopic still frames of VATS-LCSD before (B) and after (C) dissection of the pleura. VATS = video-assisted thoracic surgery.

  • Image Result
    Electrocardiogram of patient 8 before (A) and 6 months after (B) VATS-LCSD, showing a decrease in the QTc from 529 ms to 423 ms. VATS-LCSD = video-assisted thoracic surgery–left cardiac sympathetic de

    Electrocardiogram of patient 8 before (A) and 6 months after (B) VATS-LCSD, showing a decrease in the QTc from 529 ms to 423 ms. VATS-LCSD = video-assisted thoracic surgery–left cardiac sympathetic denervation.

 Dr. Ackerman's research program was supported by the Mayo Clinic Windland Smith Rice Comprehensive Sudden Cardiac Death Program, the Dr. Scholl Foundation, the CJ Foundation for SIDS, Hannah Wernke Memorial Foundation, an Established Investigator Award from the American Heart Association, and the National Institutes of Health (HD42569).

 Dr. Ackerman is a consultant for PGxHealth, Medtronic, and Pfizer.

PII: S1547-5271(09)00315-4

doi: 10.1016/j.hrthm.2009.03.024

Heart Rhythm
Volume 6, Issue 6 , Pages 752-759 , June 2009

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