Heart Rhythm
Volume 6, Issue 12 , Pages 1802-1809 , December 2009

Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation

  • Zenawit Girmatsion, MSc

      Affiliations

    • Division of Cardiology, Goethe-University, Frankfurt, Germany
    • ,
  • Peter Biliczki, MD, PhD

      Affiliations

    • Division of Cardiology, Goethe-University, Frankfurt, Germany
    • ,
  • Angelika Bonauer, PhD

      Affiliations

    • Division of Cardiology, Goethe-University, Frankfurt, Germany
    • ,
  • Gerhard Wimmer-Greinecker, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Goethe-University, Frankfurt, Germany
    • ,
  • Mirella Scherer, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Goethe-University, Frankfurt, Germany
    • ,
  • Anton Moritz, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Goethe-University, Frankfurt, Germany
    • ,
  • Alicia Bukowska, PhD

      Affiliations

    • Division of Cardiology, Otto-von-Guericke-University Hospital, Magdeburg, Germany
    • ,
  • Andreas Goette, MD

      Affiliations

    • Division of Cardiology, Otto-von-Guericke-University Hospital, Magdeburg, Germany
    • ,
  • Stanley Nattel, MD, FHRS

      Affiliations

    • Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Canada
    • ,
  • Stefan H. Hohnloser, MD, FHRS

      Affiliations

    • Division of Cardiology, Goethe-University, Frankfurt, Germany
    • ,
  • Joachim R. Ehrlich, MD

      Affiliations

    • Division of Cardiology, Goethe-University, Frankfurt, Germany
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Joachim R. Ehrlich, Division of Cardiology, Section of Electrophysiology, J. W. Goethe-Universität, Theodor Stern Kai 7, 60590 Frankfurt, Germany

Received 24 March 2009 ,Accepted 28 August 2009.

References 

  1. Nattel S, Maguy A, Le Bouter S, Yeh YH. Arrhythmogenic ion-channel remodelling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev. 2007;87:425–456
  2. Burstein B, Nattel S. Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol. 2008;51:802–809
  3. Ehrlich JR. Inward rectifier potassium currents as a target for atrial fibrillation therapy. J Cardiovasc Pharmacol. 2008;52:129–135
  4. Ehrlich JR, Cha TJ, Zhang L, et al. Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium. J Physiol. 2004;557:583–597
  5. Bosch RF, Zeng X, Grammer JB, Popovic K, Mewis C, Kuhlkamp V. Ionic mechanisms of electrical remodeling in human atrial fibrillation. Cardiovasc Res. 1999;44:121–131
  6. Dobrev D, Friedrich A, Voigt N, et al. The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation. Circulation. 2005;112:3697–3706
  7. Pandit SV, Berenfeld O, Anumonwo JM, et al. Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophys J. 2005;88:3806–3821
  8. Noujaim SF, Pandit SV, Berenfeld O, et al. Up-regulation of the inward rectifier K+ current (I K1) in the mouse heart accelerates and stabilizes rotors. J Physiol. 2007;578:315–326
  9. Xia M, Jin Q, Bendahhou S, et al. A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. Biochem Biophys Res Commun. 2005;332:1012–1019
  10. Schimpf R, Wolpert C, Gaita F, Giustetto C, Borggrefe M. Short QT syndrome. Cardiovasc Res. 2005;67:357–366
  11. Yang B, Lin H, Xiao J, et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med. 2007;13:486–491
  12. Yue L, Feng J, Li GR, Nattel S. Transient outward and delayed rectifier currents in canine atrium: properties and role of isolation methods. Am J Physiol. 1996;270:H2157–H2168
  13. Bukowska A, Lendeckel U, Hirte D, et al. Activation of the calcineurin signaling pathway induces atrial hypertrophy during atrial fibrillation. Cell Mol Life Sci. 2006;63:333–342
  14. Goette A, Bukowska A, Lendeckel U, et al. Angiotensin II receptor blockade reduces tachycardia-induced atrial adhesion molecule expression. Circulation. 2008;117:732–742
  15. Guarnieri DJ, DiLeone RJ. MicroRNAs: a new class of gene regulators. Ann Med. 2008;40:197–208
  16. Dobrev D, Graf E, Wettwer E, et al. Molecular basis of down-regulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentials. Circulation. 2001;104:2551–2557
  17. Gaborit N, Steenman M, Lamirault G, et al. Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation. 2005;112:471–481
  18. Wright M, Haissaguerre M, Knecht S, et al. State of the art: catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2008;19:583–592
  19. Sarmast F, Kolli A, Zaitsev A, et al. Cholinergic atrial fibrillation: I(K,ACh) gradients determine unequal left/right atrial frequencies and rotor dynamics. Cardiovasc Res. 2003;59:863–873
  20. Atienza F, Almendral J, Moreno J, et al. Activation of inward rectifier potassium channels accelerates atrial fibrillation in humans: evidence for a reentrant mechanism. Circulation. 2006;114:2434–2442
  21. Schram G, Pourrier M, Melnyk P, Nattel S. Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ Res. 2002;90:939–950
  22. Ehrlich JR, Cha TJ, Zhang L, et al. Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties. J Physiol. 2003;551:801–813
  23. Cherry EM, Ehrlich JR, Nattel S, Fenton FH. Pulmonary vein reentry—properties and size matter: insights from a computational analysis. Heart Rhythm. 2007;4:1553–1562
  24. Pogwizd SM, Schlotthauer K, Li L, Bers DM. Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res. 2001;88:1159–1167
  25. Kanagaratnam P, Rothery S, Patel P, Severs NJ, Peters NS. Relative expression of immunolocalized connexins 40 and 43 correlates with human atrial conduction properties. J Am Coll Cardiol. 2002;39:116–123
  26. Davis LM, Rodefeld ME, Green K, Beyer EC, Saffitz JE. Gap junction protein phenotypes of the human heart and conduction system. J Cardiovasc Electrophysiol. 1995;6:813–822
  27. Vozzi C, Dupont E, Coppen SR, Yeh HI, Severs NJ. Chamber-related differences in connexin expression in the human heart. J Mol Cell Cardiol. 1999;31:991–1003
  28. Gollob MH, Jones DL, Krahn AD, et al. Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. N Engl J Med. 2006;354:2677–2688
  29. Polontchouk L, Haefliger JA, Ebelt B, et al. Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria. J Am Coll Cardiol. 2001;38:883–891
  30. Wilhelm M, Kirste W, Kuly S, et al. Atrial distribution of connexin 40 and 43 in patients with intermittent, persistent, and postoperative atrial fibrillation. Heart Lung Circ. 2006;15:30–37
  31. Kostin S, Klein G, Szalay Z, Hein S, Bauer EP, Schaper J. Structural correlate of atrial fibrillation in human patients. Cardiovasc Res. 2002;54:361–379
  32. Kedde M, Strasser MJ, Boldajipour B, et al. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell. 2007;131:1273–1286

 Dr. Ehrlich received support from Hans und Gertie Fischer–Stiftung and Adolf Messer–Stiftung. Dr Nattel was supported by the Canadian Institutes of Health Research (MOP 44365). Dr. Biliczki was the recipient of a postdoctoral fellowship of the Deutsche Gesellschaft für Kardiologie. Mrs. Girmatsion received an award from the August Scheidel–Stiftung.

 Drs. Girmatsion and Biliczki contributed equally to this work.

 The authors thank Sabine Harenkamp for expert technical assistance.

PII: S1547-5271(09)00984-9

doi: 10.1016/j.hrthm.2009.08.035

Heart Rhythm
Volume 6, Issue 12 , Pages 1802-1809 , December 2009

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