Heart Rhythm
Volume 7, Issue 5 , Pages 708-713, May 2010

Structural basis for KV7.1–KCNEx interactions in the IKs channel complex

  • Alicia Lundby, PhD

      Affiliations

    • Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    • Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Alicia Lundby, NNF Center for Protein Research, Blegdamsvej 3B 6.2.42, DK-2200 Copenhagen N, Denmark
    • ,
  • Gea-Ny Tseng, PhD

      Affiliations

    • Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia
    • ,
  • Nicole Schmitt, PhD

      Affiliations

    • Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Received 28 September 2009; accepted 16 December 2009. published online 25 December 2009.

The cardiac IKs current is involved in action potential repolarization, where its primary function is to limit action potential prolongation during sympathetic stimulation. The IKs channel is mainly composed of KV7.1 ion channels associated with KCNE1 auxiliary subunits. The availability of KCNE1 solution structure by nuclear magnetic resonance spectroscopy in conjunction with biochemical assays addressing KV7.1–KCNE1 residue interactions has provided new insights into the structural basis for KV7.1 modulation by KCNE1. Recent evidence further suggests that KCNE2 may associate with the KV7.1–KCNE1 channel complex and modulate its current amplitude. Here we review recent studies in this area and discuss potential roles for multiple KCNEx subunits in IKs generation and modulation as well as the clinical relevance of the new information.

Keywords: IKs, KCNE1, KCNE2, KCNQ1, KV7.1

Abbreviations: IKr, cardiac rapid delayed rectifier current, IKs, cardiac slow delayed rectifier current, KV, voltage-gated potassium channel, NMR, nuclear magnetic resonance, PIP2, phosphatidylinositol 4,5-bisphosphate

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 This work was supported by the Danish National Research Foundation to Drs. Lundby and Schmitt and by the National Heart, Lung, and Blood Institute of the National Institutes of Health Grant RO1-HL67840 to Dr. Tseng.

PII: S1547-5271(09)01418-0

doi:10.1016/j.hrthm.2009.12.017

Heart Rhythm
Volume 7, Issue 5 , Pages 708-713, May 2010

Article Tools

* Image Usage & Resolution