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Heart Rhythm
Volume 7, Issue 5
, Pages 708-713
, May 2010
Structural basis for KV7.1–KCNEx interactions in the IKs channel complex
References
- . Delayed rectifier K(+) currents and cardiac repolarization. J Mol Cell Cardiol. 2010;48:37–44
- . KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval. Heart Rhythm. 2007;4:1532–1541
- Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry. 2008;47:7999–8006
- . The MinK-related peptides. Neuropharmacology. 2004;47:787–821
- Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J Physiol. 2007;582:675–693
- . Probing the interaction between KCNE2 and KCNQ1 in their transmembrane regions. J Membr Biol. 2007;216:117–127
- . Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes. Proc Natl Acad Sci U S A. 2008;105:1478–1482
- Intracellular domains interactions and gated motions of I(KS) potassium channel subunits. EMBO J. 2009;28:1994–2005
- The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. J Biol Chem. 2008;283:5815–5830
- . KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity. Neuron. 2004;42:927–937
- . Interaction of KCNE subunits with the KCNQ1 K+ channel pore. J Physiol. 2006;570:455–467
- . KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains. J Gen Physiol. 2008;131:589–603
- Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines. Proc Natl Acad Sci U S A. 2009;106:743–748
- . KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel. J Gen Physiol. 2007;130:269–281
- KCNE1 constrains the voltage sensor of Kv7.1 K+ channels. PLoS ONE. 2008;3:e1943
- Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk. Cardiovasc Res. 2000;45:971–980
- . Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. J Biol Chem. 1999;274:21063–21070
- . Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels. J Physiol. 2008;586:4179–4191
- . KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels. J Gen Physiol. 2008;131:59–68
- Differential roles of S6 domain hinges in the gating of KCNQ potassium channels. Biophys J. 2006;90:2235–2244
- . The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. J Gen Physiol. 2007;129:121–133
- . Structural determinants of KvLQT1 control by the KCNE family of proteins. J Biol Chem. 2001;276:6439–6444
- Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome. Circ Arrhythm Electrophysiol. 2008;1:209–218
- KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts. Circulation. 2004;109:1783–1788
- . KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex. FEBS J. 2008;275:1336–1349
- . A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes. ACS Chem Biol. 2007;2:469–473
- . Modulation of functional properties of KCNQ1 channel by association of KCNE1 and KCNE2. Biochem Biophys Res Commun. 2006;344:814–820
- KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heart. Heart Rhythm. 2006;3:1469–1480
- Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2. J Biol Chem. 2009;284:16452–16462
- . Dynamic complex formation during the yeast cell cycle. Science. 2005;307:724–727
This work was supported by the Danish National Research Foundation to Drs. Lundby and Schmitt and by the National Heart, Lung, and Blood Institute of the National Institutes of Health Grant RO1-HL67840 to Dr. Tseng.
PII: S1547-5271(09)01418-0
doi: 10.1016/j.hrthm.2009.12.017
© 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
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Heart Rhythm
Volume 7, Issue 5
, Pages 708-713
, May 2010
