Heart Rhythm
Volume 7, Issue 5 , Pages 577-583 , May 2010

Verapamil eliminates the hierarchical nature of activation frequencies from the pulmonary veins to the atria during paroxysmal atrial fibrillation

  • Yasunori Kushiyama, MD

      Affiliations

    • Division of Arrhythmia and Electrophysiology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan
    • Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    • ,
  • Toshiyuki Osaka, MD, PhD

      Affiliations

    • Division of Arrhythmia and Electrophysiology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Toshiyuki Osaka, Division of Arrhythmia and Electrophysiology, Shizuoka Saiseikai General Hospital, Oshika1-1-1, Suruga-ku, Shizuoka 422-8527, Japan
    • ,
  • Eriko Yokoyama, MD

      Affiliations

    • Division of Arrhythmia and Electrophysiology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan
    • ,
  • Hideyuki Hasebe, MD

      Affiliations

    • Division of Arrhythmia and Electrophysiology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan
    • ,
  • Yusuke Kuroda, MD

      Affiliations

    • Division of Arrhythmia and Electrophysiology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan
    • ,
  • Kaichiro Kamiya, MD, PhD

      Affiliations

    • Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
    • ,
  • Itsuo Kodama, MD, PhD

      Affiliations

    • Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

Received 8 November 2009 ,Accepted 5 January 2010.

References 

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  2. Suttorp MJ, Kingma JH, Lie-A-Huen L, Mast EG. Intravenous flecainide versus verapamil for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm. Am J Cardiol. 1989;63:693–696
  3. Duytschaever MF, Garratt CJ, Allessie MA. Profibrillatory effects of verapamil but not of digoxin in the goat model of atrial fibrillation. J Cardiovasc Electrophysiol. 2000;11:1375–1385
  4. Lazar S, Dixit S, Marchlinski FE, Callans DJ, Gerstenfeld EP. Presence of left-to-right atrial frequency gradient in paroxysmal but not persistent atrial fibrillation in humans. Circulation. 2004;110:3181–3186
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  7. Yokoyama E, Osaka T, Takemoto Y, et al. Paroxysmal atrial fibrillation maintained by nonpulmonary vein sources can be predicted by dominant frequency analysis of atriopulmonary electrograms. J Cariovasc Electrophysiol. 2009;20:630–636
  8. Jaïs P, Hocini M, Macle L, et al. Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillation. Circulation. 2002;106:2479–2485
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  14. Hirose M, Laurita KR. Calcium-mediated triggered activity is an underlying cellular mechanism of ectopy originating from the pulmonary vein in dogs. Am J Physiol Heart Circ Physiol. 2007;292:H1861–H1867
  15. Hassan SA, Oral H, Scharf C, et al. Rate-dependent effect of verapamil on atrial refractoriness. J Am Coll Cardiol. 2003;41:446–451
  16. Li GR, Nattel S. Properties of human atrial ICa at physiological temperatures and relevance to action potential. Am J Physiol. 1997;272:H227–H235
  17. Pandit SV, Berenfeld O, Anumonwo JM, et al. Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophys J. 2005;88:3806–3821
  18. Yamazaki M, Vaquero LM, Hou L, et al. Mechanisms of stretch-induced atrial fibrillation in the presence and the absence of adrenocholinergic stimulation: interplay between rotors and focal discharges. Heart Rhythm. 2009;6:1009–1017
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  20. Friedman HS, Rodney E, Sinha B, et al. Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect. J Investig Med. 1999;47:293–303
  21. Bénardeau A, Fareh S, Nattel S. Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs. Cardiovasc Res. 2001;50:85–96
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PII: S1547-5271(10)00010-X

doi: 10.1016/j.hrthm.2010.01.008

Heart Rhythm
Volume 7, Issue 5 , Pages 577-583 , May 2010

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