Heart Rhythm
Volume 2, Issue 11 , Pages 1231-1237 , November 2005

Atrioventricular nodal reverse facilitation in connexin40-deficient mice

  • Wei Zhu, MD

      Affiliations

    • Cardiac Arrhythmia Service, New England Medical Center, Boston, Massachusetts
    • Corresponding Author InformationAddress correspondence: Dr. Wei Zhu, Cardiovascular Research, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
  • ,
  • Samir Saba, MD

      Affiliations

    • Cardiac Arrhythmia Service, New England Medical Center, Boston, Massachusetts
  • ,
  • Mark S. Link, MD

      Affiliations

    • Cardiac Arrhythmia Service, New England Medical Center, Boston, Massachusetts
  • ,
  • Eugene Bak, MD

      Affiliations

    • Cardiac Arrhythmia Service, New England Medical Center, Boston, Massachusetts
  • ,
  • Munther K. Homoud, MD

      Affiliations

    • Cardiac Arrhythmia Service, New England Medical Center, Boston, Massachusetts
  • ,
  • N.A. Mark Estes III, MD

      Affiliations

    • Cardiac Arrhythmia Service, New England Medical Center, Boston, Massachusetts
  • ,
  • David L. Paul, PhD

      Affiliations

    • Department of Neurobiology, Harvard Medical School, Boston, Massachusetts
  • ,
  • Paul J. Wang, MD

      Affiliations

    • Stanford University Medical Center, Stanford, California
    • Corresponding Author InformationReprint requests: Paul J. Wang, MD, Cardiovascular Medicine, Stanford University Medical Center, 300 Pasteur Drive, Room H2146, Stanford, CA 94305.

Received 23 May 2005 ,Accepted 21 July 2005.

References 

  1. Goodenough DA , Goliger JA , Paul DL . Connexins, connexons, and intercellular communication . Ann Rev Biochem . 1996;65:475–502
  2. Haefliger J-A , Bruzzone R , Jenkins NA , Gilbert DJ , Copeland NG , Paul DL . Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping . J Biol Chem . 1992;267:2057–2064
  3. Barr L , Dewey MM , Berger W . Propagation of action potentials and the structure of the nexus in cardiac muscle . J Gen Physiol . 1965;48:797–823
  4. Beblo DA , Veenstra RD . Monovalent cation permeation through the connexin40 gap junctional channel. Cs, Rb, K, Na, Li, TEA, TMA, TBA, and effects of anions Br, Cl, F, acetate, aspartate, glutamate, and NO3 . J Gen Physiol . 1997;109:509–522
  5. Gros D, Jarry-Guichard T, Ten Velde I, de Maziere A, van Kempen MJA, Davoust J, et al. Restricted distribution of connexin40, a gap junctional protein, in mammalian heart . Circ Res . 1994;74:839–851
  6. Delorme B, Dahl E, Jarry-Guichard T, Marics I, Briand JP, Willecke K, et al. Developmental regulation of connexin40 gene expression in mouse heart correlates with the differentiation of the conduction system . Dev Dyn . 1995;204:358–371
  7. Gourdie RG , Lo CW . Cx43(α1) gap junctions in cardiac development and disease . Curr Top Membr . 2000;49:581–602
  8. Veenstra RD , Wang HZ , Westphale EM , Beyer EC . Multiple connexins confer distinct regulatory and conductance properties of gap junctions in developing heart . Circ Res . 1992;71:1277–1283
  9. Gourdie RG , Severs NJ , Green CR , Rothery S , Germroth P , Thompson RP . The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system . J Cell Sci . 1993;105:985–991
  10. Coppen SR , Severs NJ , Gourdie RG . Connexin 45 (α6) expression delineates an extended conduction system in the embryonic and mature rodent heart . Dev Genet . 1999;24:82–90
  11. VanderBrink BA, Sellitto C, Saba S, Link MS, Zhu W, Homoud MK, et al. Connexin40-deficient mice exhibit atrioventricular nodal and infra-Hisian conduction abnormalities . J Cardiovasc Electrophysiol . 2000;11:1270–1276
  12. Lewis T , Master AM . Observations upon conduction in the mammalian heart. AV conduction . Heart . 1925;12:209–269
  13. Mendez C , Gruhzit CC , Moe GK . The influence of cycle length upon the refractory period of the auricles, ventricles, and AV node in the dog . Am J Physiol . 1956;184;:287–295
  14. Denes P , Wu D , Dhingra R , Pietras RJ , Rosen KM . The effects of cycle length on cardiac refractory periods in man . Circulation . 1974;49:32–41
  15. Levy MN , Martin PJ , Zieske H , Adler D . Role of positive feedback in the atrioventricular nodal Wenckebach phenomenon . Circ Res . 1974;34:697–710
  16. Billette J . Preceding His-atrial interval as a determinant of atrioventricular nodal conduction time in the human and rabbit heart . Am J Cardiol . 1976;38:889–896
  17. Billette J , Janse MJ , van Capelle FJL , Anderson RH , Touboul P , Durrer D . Cycle length dependent properties of AV nodal activation in rabbit heart . Am J Physiol . 1976;231:1129–1139
  18. Billette J . Short time constant for rate-dependent changes of atrioventricular conduction in dogs . Am J Physiol . 1981;241:H26–H33
  19. Billette J , Metayer R . Origin, domain and dynamics of rate-induced variations of functional refractory period in rabbit atrioventricular node . Circ Res . 1989;65:164–175
  20. Talajic M , Papadatos D , Villemaire C , Glass L , Nattel S . A unified model of atrioventricular nodal conduction predicts dynamic changes in Wenckebach periodicity . Circ Res . 1991;68:1280–1293
  21. Nayebpour M , Talajic M , Nattel S . Quantitation of dynamic AV nodal properties and application to predict rate-dependent AV conduction . Am J Physiol . 1991;261:H292–H300
  22. Billette J , Nattel S . Dynamic behavior of the atrioventricular node (a functional model of interaction between recovery, facilitation, and fatigue) . J Cardiovasc Electrophysiol . 1994;5:90–102
  23. Fahy GJ, Efimov I, Cheng Y, Kidwell GA, van Wagoner D, Tchou PJ, et al. Mechanism of atrioventricular nodal facilitation in the rabbit heart (role of the distal AV node) . Am J Physiol . 1997;272:H2815–H2825
  24. Mazgalev T, Mowrey K, Efimov I, Fahy GJ, van Wagoner D, Cheng Y, et al. Mechanism of atrioventricular nodal facilitation in rabbit heart (role of proximal AV node) . Am J Physiol . 1997;273:H1658–H1668
  25. Zhu W, Lepore JJ, Saba S, Joseph S, Link MS, Homoud MK, et al. Cardiac electrophysiologic abnormalities in the CREBA133 transgenic mouse model of idiopathic dilated cardiomyopathy . J Cardiovasc Electrophysiol . 2003;14:982–989
  26. Saba S , London B , Ganz L . Autonomic blockade unmasks maturational differences in rate-dependent atrioventricular nodal conduction and facilitation in the mouse . J Cardiovasc Electrophysiol . 2003;14:191–195
  27. Verheule S , van Batenburg CA , Coenjaerts FE , Kirchhoff S , Willecke K , Jongsma HJ . Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40 . J Cardiovasc Electrophysiol . 1999;10:1380–1389
  28. Gu H , Smith FC , Taffet SM , Delmar M . High incidence of cardiac malformations in connexin40-deficient mice . Circ Res . 2003;93:201–206

PII: S1547-5271(05)01887-4

doi: 10.1016/j.hrthm.2005.07.022

Heart Rhythm
Volume 2, Issue 11 , Pages 1231-1237 , November 2005