Heart Rhythm
Volume 3, Issue 3 , Pages 296-310 , March 2006

Electrocardiographic imaging of cardiac resynchronization therapy in heart failure: Observation of variable electrophysiologic responses

  • Ping Jia, PhD

      Affiliations

    • Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio
  • ,
  • Charulatha Ramanathan, PhD

      Affiliations

    • Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio
  • ,
  • Raja N. Ghanem, PhD

      Affiliations

    • Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio
  • ,
  • Kyungmoo Ryu, PhD

      Affiliations

    • Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio
  • ,
  • Niraj Varma, MD

      Affiliations

    • Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio
    • University Hospitals of Cleveland, Cleveland, Ohio
  • ,
  • Yoram Rudy, PhD

      Affiliations

    • Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, Missouri
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Yoram Rudy, Cardiac Bioelectricity & Arrhythmia Center, Washington University in St. Louis, Campus Box 1097, 290 Whitaker Hall, One Brookings Drive, St. Louis, Missouri 63130-4899

Received 2 August 2005 ,Accepted 22 November 2005.

References 

  1. Farwell D , Patel NR , Hall A , Ralph S , Sulke AN . How many people with heart failure are appropriate for biventricular resynchronization? . Eur Heart J . 2000;21:1246–1250
  2. Cleland JGF, Daubert J-C, Erdmann E, Freemantle N, Gras D, Kappenberger L, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure . N Engl J Med . 2005;352:1539–1549
  3. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, et al. Cardiac resynchronization in chronic heart failure . N Engl J Med . 2002;346:1845–1853
  4. Auricchio A, Stellbrink C, Block M, Sack S, Vogt J, Bakker P, et al. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure . Circulation . 1999;99:2993–3001
  5. Nelson GS, Curry CW, Wyman BT, Kramer A, Declerck J, Talbot M, et al. Predictors of systolic augmentation from left ventricular preexcitation in patients with dilated cardiomyopathy and intraventricular conduction delay . Circulation . 2000;101:2703–2709
  6. Oster HS , Taccardi B , Lux RL , Ershler PR , Rudy Y . Noninvasive electrocardiographic imaging (reconstruction of epicardial potentials, electrograms, and isochrones and localization of single and multiple electrocardiac events) . Circulation . 1997;96:1012–1024
  7. Burnes JE , Taccardi B , MacLeod RS , Rudy Y . Noninvasive ECG imaging of electrophysiologically abnormal substrates in infarcted hearts (a model study) . Circulation . 2000;101:533–540
  8. Burnes JE , Taccardi B , E PR , Rudy Y . Noninvasive electrocardiogram imaging of substrate and intramural ventricular tachycardia in infarcted hearts . J Am Coll Cardiol . 2001;38:2071–2078
  9. Burnes JE , Ghanem RN , Waldo AL , Rudy Y . Imaging dispersion of myocardial repolarization, I (comparison of body-surface and epicardial measures) . Circulation . 2001;104:1299–1305
  10. Ghanem RN , Burnes JE , Waldo AL , Rudy Y . Imaging dispersion of myocardial repolarization, II (noninvasive reconstruction of epicardial measures) . Circulation . 2001;104:1306–1312
  11. Ramanathan C , Ghanem RN , Jia P , Ryu K , Rudy Y . Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia . Nat Med . 2004;10:422–428
  12. Ghanem R , Ramanathan C , Jia P , Ryu K , Markowitz A , Rudy Y . Noninvasive electrocardiographic imaging (ECGI) (comparison to intraoperative mapping in patients) . Heart Rhythm . 2005;2:339–354
  13. Intini A, Goldstein RN, Jia P, Ramanathan C, Ryu K, Giannattasio B, et al. Electrocardiographic imaging (ECGI), a novel diagnostic modality used for mapping of focal left ventricular tachycardia in a young athlete . Heart Rhythm . 2005;2:1250–1252
  14. Ghosh S , Rudy Y . Accuracy of quadratic versus linear interpolation in noninvasive electrocardiographic imaging (ECGI) . Ann Biom Eng . 2005;33:1187–1201
  15. Ritter P , Padeletti L , Gillio-Meina L , Gaggini G . Determination of the optimal atrioventricular delay in DDD pacing. Comparison between echo and peak endocardial acceleration measurements . Europace . 1999;1:126–130
  16. Ramanathan C , Jia P , Ghanem R , Ryu K , Rudy Y . Noninvasive electrocardiographic imaging (ECGI) of normal activation and repolarization of the human heart (abstr) . Pacing Clin Electrophysiol . 2003;26(pt II): II-995
  17. Auricchio A, Fantoni C, Regoli F, Carbucicchio C, Goette A, Geller C, et al. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block . Circulation . 2004;109:1133–1139
  18. Fung JW, Yu CM, Yip G, Zhang Y, Chan H, Kum CC, et al. Variable left ventricular activation pattern in patients with heart failure and left bundle branch block . Heart (Br Card Soc) . 2004;90:17–19
  19. Butter C, Auricchio A, Stellbrink C, Fleck E, Ding J, Yu Y, et al. Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients . Circulation . 2001;104:3026–3029
  20. Ansalone G , Giannantoni P , Ricci R , Trambaiolo P , Fedele F , Santini M . Doppler myocardial imaging to evaluate the effectiveness of pacing sites in patients receiving biventricular pacing . J Am Coll Cardiol . 2002;39:489–499
  21. Kass DA . Ventricular resynchronization (pathophysiology and identification of responders) . Rev Cardiovasc Med . 2003;4(suppl 2):S3–S13
  22. Tse H-F, Lee KL, Wan S-H, Yu Y, Hoersch W, Pastore J, et al. Area of left ventricular regional conduction delay and preserved myocardium predict responses to cardiac resynchronization therapy . J Cardiovasc Electrophysiol . 2005;16:690–695
  23. Yu Y , Kramer A , Spinelli J , Ding J , Hoersch W , Auricchio A . Biventricular mechanical asynchrony predicts hemodynamic effect of uni- and biventricular pacing . Am J Physiol Heart Circ Physiol . 2003;285:H2788–H2796
  24. Leclercq C, Faris O, Tunin R, Johnson J, Kato R, Evans F, et al. Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block . Circulation . 2002;106:1760–1763
  25. Lambiase PD, Rinaldi A, Hauck J, Mobb M, Elliott D, Mohammad S, et al. Non-contact left ventricular endocardial mapping in cardiac resynchronisation therapy . Heart (Br Card Soc) . 2004;90:44–51
  26. Bordachar P, Lafitte S, Reuter S, Sanders P, Jaïs P, Haïssaguerre M, et al. Echocardiographic parameters of ventricular dyssynchrony validation in patients with heart failure using sequential biventricular pacing . J Am Coll Cardiol . 2004;44:2157–2165

 The study was supported by Merit Award R37-HL-33343 and Grant R01-HL-49054 from the National Heart, Lung, and Blood Institute of the National Institutes of Health to Dr. Rudy. Dr. Rudy is the Fred Saigh Distinguished Professor at Washington University in St. Louis. Drs. Jia and Ramanathan are employees and stockholders of Cardioinsight, Inc., a company that plans to commercialize electrocardiographic imaging as a clinical tool. Dr. Rudy is a coinventor of the ECGI technology.

PII: S1547-5271(05)02359-3

doi: 10.1016/j.hrthm.2005.11.025

Heart Rhythm
Volume 3, Issue 3 , Pages 296-310 , March 2006