Heart Rhythm
Volume 3, Issue 6 , Pages 660-664 , June 2006

Beat-to-beat QT dynamics in paroxysmal atrial fibrillation

  • Charlotte E. Larroude, MD

      Affiliations

    • Laboratory of Experimental Cardiology, Department of Medical Physiology, University of Copenhagen, Copenhagen, Denmark
    • Department of Medicine, Elsinore Hospital, Helsingør, Denmark
    • Danish Arrhythmia Research Center (DARC), Copenhagen, Denmark.
  • ,
  • Berit T. Jensen, MD, PhD

      Affiliations

    • Laboratory of Experimental Cardiology, Department of Medical Physiology, University of Copenhagen, Copenhagen, Denmark
    • Department of Medicine, Elsinore Hospital, Helsingør, Denmark
    • Danish Arrhythmia Research Center (DARC), Copenhagen, Denmark.
  • ,
  • Erik Agner, MD, PhD

      Affiliations

    • Department of Medicine, Elsinore Hospital, Helsingør, Denmark
  • ,
  • Egon Toft, MD, PhD

      Affiliations

    • Department of Cardiology, Aalborg Hospital, Århus University Hospital, Aalborg, Denmark
    • Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
  • ,
  • Christian Torp-Pedersen, MD, PhD

      Affiliations

    • Department of Cardiology, Bispebjerg Hospital, Copenhagen, Denmark
  • ,
  • Kristian Wachtell, MD, PhD

      Affiliations

    • Department of Medicine, Glostrup University Hospital, Glostrup, Denmark
    • Department of Cardiology B, The Heart Center, Rigshospitalet, Copenhagen, Denmark
  • ,
  • Jørgen K. Kanters, MD

      Affiliations

    • Laboratory of Experimental Cardiology, Department of Medical Physiology, University of Copenhagen, Copenhagen, Denmark
    • Department of Medicine, Elsinore Hospital, Helsingør, Denmark
    • Danish Arrhythmia Research Center (DARC), Copenhagen, Denmark.
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Jørgen K. Kanters, Laboratory of Experimental Cardiology, University of Copenhagen, Blegdamsvej 3C, DK2200 Copenhagen N, Denmark.

Received 15 December 2005 ,Accepted 15 February 2006.

References 

  1. Jensen BT, Abildstrom SZ, Larroude CE, Agner E, Torp-Pedersen C, Nyvad O, et al. QT dynamics in risk stratification after myocardial infarction . Heart Rhythm . 2005;2:357–364
  2. Yeragani VK , Adiga S , Desai N , Berger RD . Beat-to-beat QT interval variability in atrial fibrillation with and without congestive cardiac failure . Ann Noninvas Electrocardiol . 2004;9:304–305
  3. Pai GR , Rawles JM . The QT interval in atrial fibrillation . Br Heart J . 1989;61:510–513
  4. Franz MR , Swerdlow CD , Liem LB , Schaefer J . Cycle length dependence of human action potential duration in vivo. Effects of single extrastimuli, sudden sustained rate acceleration and deceleration, and different steady-state frequencies . J Clin Invest . 1988;82:972–979
  5. Pueyo E , Smetana P , Laguna P , Malik M . Estimation of the QT/RR hysteresis lag . J Electrocardiol . 2003;36:187–190
  6. Lau CP , Freedman AR , Fleming S , Malik M , Camm AJ , Ward DE . Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate . Cardiovasc Res . 1988;22:67–72
  7. Sarma JS , Venkataraman SK , Samant DR , Gadgil U . Hysteresis in the human RR-QT relationship during exercise and recovery . Pacing Clin Electrophysiol . 1987;10:485–491
  8. Pueyo E , Smetana P , Malik P , Laguna Lasaosa P . Evaluation of QT interval response to marked RR interval changes selected automatically in ambulatory recordings . Comput Cardiol . 2003;30:157–160
  9. Ehlert FA , Goldberger JJ , Rosenthal JE , Kadish AH . Relation between QT and RR intervals during exercise testing in atrial fibrillation . Am J Cardiol . 1992;70:332–338
  10. Bonnemeier H, Wiegand UKH, Bode F, Hartmann F, Kurowski V, Katus HA, et al. Impact of infarct-related artery flow on QT dynamicity in patients undergoing direct percutaneous coronary intervention for acute myocardial infarction . Circulation . 2003;108:2979–2986
  11. Pathak A, Curnier D, Fourcade J, Roncalli J, Stein PK, Hermant P, et al. QT dynamicity (a prognostic factor for sudden cardiac death in chronic heart failure) . Eur J Heart Fail . 2005;7:269–275
  12. Extramiana F , Maison-Blanche P , Badilini F , Pinoteau J , Deseo T , Coumel P . Circadian modulation of QT rate dependence in healthy volunteers (gender and age differences) . J Electrocardiol . 1999;32:33–43
  13. Berger RD , Kasper EK , Baughman KL , Marban E , Calkins H , Tomaselli GF . Beat-to-beat QT interval variability (novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy) . Circulation . 1997;96:1557–1565
  14. Jensen BT, Larroude CE, Rasmussen LP, Holstein-Rathlou NH, Hojgaard MV, Agner E, et al. Beat-to-beat QT dynamics in healthy subjects . Ann Noninvas Electrocardiol . 2004;9:3–11
  15. Alonso JL, Martinez P, Vallverdu M, Cygankiewicz I, Pitzalis MV, Genis AB, et al. Dynamics of ventricular repolarization in patients with dilated cardiomyopathy versus healthy subjects . Ann Noninvas Electrocardiol . 2005;10:121–128
  16. Chevalier P, Burri H, Adeleine P, Kirkorian G, Lopez M, Leizorovicz A, et al. QT dynamicity and sudden death after myocardial infarction:. results of a long-term follow-up study . J Cardiovasc Electrophysiol . 2003;14:227–233
  17. Haigney MC, Zareba W, Gentlesk PJ, Goldstein RE, Illovsky M, McNitt S, et al. QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients . J Am Coll Cardiol . 2004;44:1481–1487
  18. Laguna P, Thakor NV, Caminal P, Jane R, Yoon HR, Bayes de Luna A, et al. New algorithm for QT interval analysis in 24-hour Holter ECG (performance and applications) . Med Biol Eng Comput . 1990;28:67–73
  19. Abildstrom SZ, Jensen BT, Agner E, Torp-Pedersen C, Nyvad O, Wachtell K, et al. Heart rate versus heart rate variability in risk prediction after myocardial infarction . J Cardiovasc Electrophysiol . 2003;14:168–173
  20. Ho KKL, Moody GB, Peng CK, Mietus JE, Larson MG, Levy D, et al. Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics . Circulation . 1997;96:842–898
  21. Bazett HC . An analysis of the time-relations of electrocardiograms . Heart . 1920;7:353–368
  22. Boriani G, Valzania C, Biffi M, Corazza I, Camanini C, Martignani C, et al. Increase in QT/QTc dispersion after low energy cardioversion of chronic persistent atrial fibrillation . Int J Cardiol . 2004;95:245–250
  23. Ishida S , Takahashi N , Nakagawa M , Fujino T , Saikawa T , Ito M . Relation between QT and RR intervals in patients with bradyarrhythmias . Br Heart J . 1995;74:159–162
  24. Tetsuya K, Naohiko T, Yasukazu S, Takeshi T, Masahide H, Tetsunori S, et al. Cumulative effect of preceding pacing cycle length on ventricular repolarization after a pause . Pacing Clin Electrophysiol . 2002;25:1324–1347
  25. Castellanos A , Moleiro F , Lopera G , Huikuri H , Interian A , Myerburg RJ . Dynamics of the uncorrected QT interval during vagal-induced lengthening of RR intervals . Am J Cardiol . 2000;86:1390–1392 A6
  26. Seed WA, Noble MI, Oldershaw P, Wanless RB, Drake-Holland AJ, Redwood D, et al. Relation of human cardiac action potential duration to the interval between beats (implications for the validity of rate corrected QT interval (QTc)) . Br Heart J . 1987;57:32–37
  27. Malik M , Janota T , Nagayoshi H , Hnatkova K , Camm AJ . Changes of QT intervals associated with postural change in patients with chronic atrial fibrillation . Pacing Clin Electrophysiol . 1996;19:490–495
  28. Lux RL , Ershler PR . Cycle length sequence dependent repolarization dynamics . Journal of Electrocardiology . 2003;36:205–208

 This study was supported by grants from the Danish Heart Foundation, the Danish National Research Foundation, and The Research Foundation of Frederiksborg County.

PII: S1547-5271(06)00183-4

doi: 10.1016/j.hrthm.2006.02.021

Heart Rhythm
Volume 3, Issue 6 , Pages 660-664 , June 2006