Heart Rhythm
Volume 3, Issue 10 , Pages 1175-1181 , October 2006

Quantitative assessment of ST segment elevation in Brugada patients

  • Fabrice Extramiana, MD, PhD

      Affiliations

    • Lariboisière University Hospital, Paris, France
    • Corresponding Author InformationAddress reprint requests and correspondence: Fabrice Extramiana, Cardiology Department, Lariboisière University Hospital, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France.
    • ,
  • Julien Seitz, MD

      Affiliations

    • Lariboisière University Hospital, Paris, France
    • ,
  • Pierre Maison-Blanche, MD

      Affiliations

    • Lariboisière University Hospital, Paris, France
    • ,
  • Fabio Badilini, PhD

      Affiliations

    • AMPS, LLC, New York, New York
    • ,
  • Abdeddayem Haggui, MD

      Affiliations

    • Lariboisière University Hospital, Paris, France
    • ,
  • Seiji Takatsuki, MD

      Affiliations

    • Lariboisière University Hospital, Paris, France
    • ,
  • Paul Milliez, MD, PhD

      Affiliations

    • Lariboisière University Hospital, Paris, France
    • ,
  • Isabelle Denjoy, MD

      Affiliations

    • Lariboisière University Hospital, Paris, France
    • ,
  • Bruno Cauchemez, MD

      Affiliations

    • Lariboisière University Hospital, Paris, France
    • ,
  • Philippe Beaufils, MD

      Affiliations

    • Lariboisière University Hospital, Paris, France
    • ,
  • Antoine Leenhardt, MD

      Affiliations

    • Lariboisière University Hospital, Paris, France

Received 21 April 2006 ,Accepted 8 June 2006.

References 

  1. Brugada P , Brugada J . Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome (A multicenter report) . J Am Coll Cardiol . 1992;20:1391–1396
  2. Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, et al. Proposed diagnostic criteria for the Brugada syndrome (Consensus report) . Circulation . 2002;106:2514–2519
  3. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association . Circulation . 2005;111:659–670
  4. Brugada J , Brugada P . Further characterization of the syndrome of right bundle branch block, ST segment elevation, and sudden cardiac death . J Cardiovasc Electrophysiol . 1997;8:325–331
  5. Brugada R, Brugada J, Antzelevitch C, Kirsch GE, Potenza D, Towbin JA, et al. Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts . Circulation . 2000;101:510–515
  6. Antzelevitch C . Brugada syndrome: overview . In:  Antzelevitch C editors. The Brugada syndrome (From bench to bedside) . Malden, MA: Blackwell Futura; 2005;p. 1–22
  7. Matsuo K, Kurita T, Inagaki M, Kakishita M, Aihara N, Shimizu W, et al. The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome . Eur Heart J . 1999;20:465–470
  8. Vatta M, Dumaine R, Varghese G, Richard TA, Shimizu W, Aihara N, et al. Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome . Hum Mol Genet . 2002;11:337–345
  9. Miyazaki T , Mitamura H , Miyoshi S , Soejima K , Aizawa Y , Ogawa S . Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome . J Am Coll Cardiol . 1996;27:1061–1070
  10. Yan GX , Antzelevitch C . Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation . Circulation . 1999;100:1660–1666
  11. Boyett MR . A study of the effect of the rate of stimulation on the transient outward current in sheep cardiac Purkinje fibres . J Physiol . 1981;319:1–22
  12. Badilini F , Maison-Blanche P , Childers R , Coumel P . QT interval analysis on ambulatory electrocardiogram recordings: a selective beat averaging approach . Med Biol Eng Comput . 1999;37:71–79
  13. Badilini F , Maison-Blanche P . Holter monitoring for QT: The RR bin method in depth . In:  Morganroth J ,  Gussak I editor. Cardiac safety of noncardiac drugs (Practical guidelines for clinical research and drug development) . Totowa, N.J: Humana Press; 2004;
  14. Extramiana F , Maison-Blanche P , Cabanis MJ , Ortemann-Renon C , Beaufils P , Leenhardt A . Clinical assessment of drug-induced QT prolongation when associated with heart rate changes . Clin Pharmacol Ther . 2005;77:247–258
  15. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology . Heart rate variability: standards of measurement, physiological interpretation and clinical use . Circulation . 1996;93:1043–1065
  16. Badilini F , Maison-Blanche P , Champomier P , Provost JC , Coumel P , Milon H . Frequency-domain heart rate variability in 24-hour Holter recordings: role of spectral method to assess circadian patterns and pharmacological autonomic modulation . J Electrocardiol . 2000;33:147–157
  17. Brugada J , Brugada R , Antzelevitch C , Towbin J , Nademanee K , Brugada P . Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3 . Circulation . 2002;105:73–78
  18. Mizumaki K, Fujiki A, Tsuneda T, Sakabe M, Nishida K, Sugao M, et al. Vagal activity modulates spontaneous augmentation of ST elevation in the daily life of patients with Brugada syndrome . J Cardiovasc Electrophysiol . 2004;15:667–673
  19. Di Diego JM, Cordeiro JM, Goodrow RJ, Fish JM, Zygmunt AC, Perez GJ, et al. Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males . Circulation . 2002;106:2004–2011
  20. Kimura M, Kobayashi T, Owada S, Ashikaga K, Higuma T, Sasaki S, et al. Mechanism of ST elevation and ventricular arrhythmias in an experimental Brugada syndrome model . Circulation . 2004;109:125–131
  21. Nishida K, Fujiki A, Mizumaki K, Sakabe M, Sugao M, Tsuneda T, et al. Canine model of Brugada syndrome using regional epicardial cooling of the right ventricular outflow tract . J Cardiovasc Electrophysiol . 2004;15:936–941
  22. Litovsky SH , Antzelevitch C . Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of transient outward current . J Am Coll Cardiol . 1989;14:1053–1066
  23. Chang MS , Zipes DP . Differential sensitivity of sinus node, atrioventriculaire node, atrium and ventricle to propranolol . Am Heart J . 1988;116:371–378
  24. Levy MN , Martin P . Parasympathetic control of the heart . In:  Randall WC editors. Nervous control of cardiovascular function . Oxford: Oxford University Press; 1984;p. 68–94
  25. Levy MN . Cardiac sympathetic-parasympathetic interactions . Fed Proc . 1984;43:2598–2602
  26. Litovsky SH , Antzelevitch C . Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol (A direct effect of acetylcholine in ventricular myocardium) . Circ Res . 1990;67:615–627

 Fabio Badilini is vice president of AMPS LLC, New York. Part of the study was done using the Winatrec software commercialized by AMPS.

PII: S1547-5271(06)01613-4

doi: 10.1016/j.hrthm.2006.06.010

Heart Rhythm
Volume 3, Issue 10 , Pages 1175-1181 , October 2006

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