Heart Rhythm
Volume 4, Issue 4 , Pages 499-507 , April 2007

Ionic mechanisms underlying region-specific remodeling of rabbit atrial action potentials caused by intermittent burst stimulation

  • Wen Dun, PhD

      Affiliations

    • Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York
  • ,
  • Nazira Özgen, MD, PhD

      Affiliations

    • Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York
  • ,
  • Masanori Hirose, MD

      Affiliations

    • Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York
    • Center for Molecular Therapeutics, College of Physicians and Surgeons, Columbia University, New York, New York.
  • ,
  • Eugene A. Sosunov, PhD

      Affiliations

    • Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York
    • Center for Molecular Therapeutics, College of Physicians and Surgeons, Columbia University, New York, New York.
  • ,
  • Evgeny P. Anyukhovsky, PhD

      Affiliations

    • Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York
    • Center for Molecular Therapeutics, College of Physicians and Surgeons, Columbia University, New York, New York.
  • ,
  • Michael R. Rosen, MD

      Affiliations

    • Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York
    • Center for Molecular Therapeutics, College of Physicians and Surgeons, Columbia University, New York, New York.
  • ,
  • Penelope A. Boyden, PhD

      Affiliations

    • Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York
    • Center for Molecular Therapeutics, College of Physicians and Surgeons, Columbia University, New York, New York.
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Penelope A. Boyden, Department of Pharmacology, Columbia University, 630 West 168th Street, P&S 7-446, New York, New York 10032.

Received 25 October 2006 ,Accepted 13 December 2006.

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 This study was supported by NHLBI HL-28958, 67101, HL-66140. The first two authors contributed equally to this study.

PII: S1547-5271(06)02300-9

doi: 10.1016/j.hrthm.2006.12.032

Heart Rhythm
Volume 4, Issue 4 , Pages 499-507 , April 2007