Heart Rhythm
Volume 4, Issue 6 , Pages 768-778 , June 2007

Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: Analysis of the I1768V SCN5A mutation

  • Sarah N. Flaim, PhD

      Affiliations

    • Now at Oxford University Computing Laboratory, University of Oxford, United Kingdom
    • ,
  • Wayne R. Giles, PhD

      Affiliations

    • now at Faculties of Kinesiology and Medicine, University of Calgary, Calgary, Canada.
    • ,
  • Andrew D. McCulloch, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Andrew McCulloch, Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0412, La Jolla, California 92093-0412.

Received 23 August 2006 ,Accepted 7 February 2007.

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 This work was supported by an American Heart Association Predoctoral Fellowship to Dr. Flaim, the National Biomedical Computation Resource (P 41 RR08605) to Dr. McCulloch, and the National Science Foundation (BES-0506252 to Dr. McCulloch.

PII: S1547-5271(07)00151-8

doi: 10.1016/j.hrthm.2007.02.009

Heart Rhythm
Volume 4, Issue 6 , Pages 768-778 , June 2007

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