Heart Rhythm
Volume 4, Issue 8 , Pages 1024-1028 , August 2007

The effect of atrial-based pacing on exercise capacity as measured by the 6-minute walk test: A substudy of the Canadian Trial of Physiological Pacing (CTOPP)

  • Adrian Baranchuk, MD

      Affiliations

    • Queen’s University, Kingston, Ontario, Canada
    • ,
  • Jeff S. Healey, MD

      Affiliations

    • The Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    • Dr. Healey is supported by a fellowship grant from the Heart and Stroke Foundation of Canada and Astra-Zeneca Canada Ltd.
    • Corresponding Author InformationAddress reprint requests and correspondence: Jeff S. Healey, McMaster University, 237 Barton Street East, Hamilton, Ontario, Canada, L8L 2X2.
    • ,
  • Kevin E. Thorpe, MMath

      Affiliations

    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Carlos A. Morillo, MD, FACC

      Affiliations

    • The Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Girish Nair, MD

      Affiliations

    • The Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Eugene Crystal, MD

      Affiliations

    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Charles R. Kerr, MD, FACC

      Affiliations

    • University of British Columbia, Vancouver, British Columbia, Canada.
    • ,
  • Stuart J. Connolly, MD, FACC

      Affiliations

    • The Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    • ,
  • CTOPP Investigators

Received 26 February 2006 ,Accepted 31 March 2007.

References 

  1. Connolly SJ, Kerr CR, Gent M, Roberts RS, Yusuf S, Gillis AM, et al. Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. N Eng J Med. 2000;342:1385–1391
  2. Kerr CR, Connolly SJ, Abdollah H, Roberts RS, Gent M, Yusuf S, et al. Canadian trial of physiologic pacing: Effects of physiologic pacing during long-term follow-up. Circulation. 2004;109:357–362
  3. Tang ASL, Roberts RS, Kerr CR, Gillis AM, Green MS, Talajic M, et al. Relationship between pacemaker dependency and the effect of pacing mode on cardiovascular outcomes. Circulation. 2001;103:3081–3085
  4. Lamas GA, Lee KL, Sweeny MO, Silverman R, Leon A, Yee R, et al. Ventricular pacing or dual-chamber pacing for sinus-node dysfunction. N Eng J Med. 2002;346:1854–1862
  5. Guyatt GH, Sullivan MJ, Thompson PJ, Fallen EL, Pugsley SO, Taylor DW, et al. The 6-minute walk test: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J. 1985;132:923
  6. Enright PL. The six-minute walk test. Respir Care. 2003;48:783–785
  7. Enright PL, McBurnie MA, Bittner V, Tracy RP, Mcnamara R, Arnold A, et al. Cardiovascular Health Study. The six-minute walk test. A quick measure of functional status in elderly adults. Chest. 2003;123:387–398
  8. Curtis JP, Rathore SS, Wang Y, Krumholz HM. The association of 6-minute walk performance and outcomes in stable outpatients with heart failure. J Card Fail. 2004;10:9–14
  9. Cahalin LP, Mathier MA, Semigran MJ, Dec GW, DiSalvo TG. The six-minute walk test predicts peak oxygen uptake and survival in patients with advanced heart failure. Chest. 1996;110:325–332
  10. Demers C, McKelvie RS, Negassa A, Yusuf S RESOLVD Pilot Study Investigators. Reliability, validity and responsiveness of the six-minute walk test in patients with heart failure. Am Heart J. 2001;142:698–703
  11. O’Keefe ST, Lye M, Donnellan C, Carmichael DN. Reproducibility and responsiveness of quality of life assessment and six minute walk test in elderly heart failure patients. Heart. 1998;80:377–382
  12. Bittner V, Weiner DH, Yusuf S, Rogers WJ, McIntyre KM, Bangdowala SI, et al. Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction. JAMA. 1993;270:1702–1707
  13. McKelvie RS, Teo KK, Roberts RS, McCartney N, Humen D, Montague T, et al. Effect of exercise training in patients with heart failure: The Exercise Rehabilitation Trial (EXERT). Am Heart J. 2002;144:23–30
  14. Nordlander R, Hedman A, Pehrson SK. Rate responsive pacing and exercise capacity—A comment. Pacing Clin Electrophysiol. 1989;12:749–751
  15. Langenfeld H, Schneider B, Grimm W, Beer M, Knoche M, Riegger G, et al. The six-minute walk (An adequate exercise for pacemaker patients?). Pacing Clin Electrophysiol. 1990;13:1761–1765
  16. Oto MA, Muderrisoglu H, Ozin MB, Korkmaz ME, Karamehmetoglu A, Oram A, et al. Quality of life in patients with rate responsive pacemakers: a randomized, cross-over study. Pacing Clin Electrophysiol. 1991;14:800–806
  17. Payne GE, Skehan JD. Shuttle walking test: a new approach for evaluating patients with pacemakers. Heart. 1996;75:414–418
  18. Deharo JC, Badier M, Thirion X, Ritter P, Provenier F, Graux P, et al. A randomized, single-blind crossover comparison of the effects of chronic DDD and dual sensor VVIR pacing mode on quality of life and cardiopulmonary performance in complete heart block. Pacing Clin Electrophysiol. 1996;19:1320–1326
  19. Provenier F, Jordaens L. Evaluation of six minute walking test in patients with single chamber rate responsive pacemakers. Br Heart J. 1994;72:192–196
  20. Gibbons WJ, Fruchter N, Sloan S, Levy RD. Reference values for a multiple repetition 6-minute walk test in healthy adults older than 20 years. J Cardiopulm Rehabil. 2001;21:87–93
  21. Lau CP, Camm AJ. Overview of ideal sensor characteristics. In: Clinical Cardiac Pacing. Philadelphia, PA: WB Saunders Co; 1995;p. 141–166
  22. Link MS, Hellkamp AS, Estes NA, Orav EJ, Ellenbogen KA, Ibrahim B, et al. High incidence of pacemaker syndrome in patients with sinus node dysfunction treated with ventricular-based pacing in the Mode Selection Trial (MOST). J Am Coll Cardiol. 2004;43:2066–2071
  23. Newman D, Lau C, Tang AS, Irvine J, Paquette M, Woodend K, et al. Effect of pacing mode on health-related quality of life in the Canadian Trial of Physiologic Pacing. Am Heart J. 2003;145:430–437
  24. Fleischmann KE, Orav EJ, Lamas GA, Mangione CM, Schron EB, Lee KL, et al. Pacemaker implantation and quality of life in the Mode Selection Trial (MOST). Heart Rhythm. 2006;3:653–659
  25. Khairy P, Talajic M, Dominguez M, Tardiff JC, Juneau M, Lavoie L, et al. Atrioventricular interval optimization and exercise tolerance. Pacing Clin Electrophysiol. 2001;24:1434–1440

 This study was supported by the Medical Research Council of Canada.

PII: S1547-5271(07)00408-0

doi: 10.1016/j.hrthm.2007.03.042

Heart Rhythm
Volume 4, Issue 8 , Pages 1024-1028 , August 2007

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