Heart Rhythm
Volume 5, Issue 5 , Pages 734-741 , May 2008

Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model

  • Torben Peitersen, MSc

      Affiliations

    • Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark
    • ,
  • Morten Grunnet, PhD

      Affiliations

    • Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark
    • NeuroSearch A/S, Ballerup, Denmark.
    • ,
  • Alan P. Benson, PhD

      Affiliations

    • Computational Biology Laboratory, Institute of Membrane and Systems Biology, University of Leeds, Leeds, United Kingdom
    • ,
  • Arun V. Holden, PhD

      Affiliations

    • Computational Biology Laboratory, Institute of Membrane and Systems Biology, University of Leeds, Leeds, United Kingdom
    • ,
  • Niels-Henrik Holstein-Rathlou, MD, PhD

      Affiliations

    • Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark
    • ,
  • Søren-Peter Olesen, MD, PhD

      Affiliations

    • Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Søren-Peter Olesen, Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.

Received 30 November 2007 ,Accepted 23 February 2008.

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 The work was supported by the Danish National Research Foundation to Drs. Holstein-Rathlou, Olesen, Peitersen, and Grunnet; The Medical Research Council, UK to Dr. Benson; and The European Union through the Network of Excellence BioSim, Contract No. LHSB-CT-2004-005137, to Drs. Holden, Benson, Holstein-Rathlou, and Peitersen. Dr. Grunnet is an employee of NeuroSearch and Dr. Olesen is consultant to the company, which owns the rights to the compound NS1643.

PII: S1547-5271(08)00207-5

doi: 10.1016/j.hrthm.2008.02.026

Heart Rhythm
Volume 5, Issue 5 , Pages 734-741 , May 2008

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