Heart Rhythm
Volume 6, Issue 5 , Pages 658-662 , May 2009

Arrhythmogenicity of weight-loss supplements marketed on the Internet

This paper was presented as an oral abstract at Heart Rhythm 2008, San Francisco, California.

References 

  1. Overweight and obesity. http://www.cdc.gov/nccdphp/dnpa/obesity/. Accessed February 2008.
  2. Blanck HM, Serdula MK, Gillespie C, et al. Use of nonprescription dietary supplements for weight loss is common among Americans. J Am Diet Assoc. 2007;107:441–447
  3. Pillitteri JL, Shiffman S, Rohay JM, et al. Use of dietary supplements for weight loss in the United States: results of a national survey. Obesity (Silver Spring). 2008;16:790–796
  4. Saper RB, Eisenberg DM, Phillips RS. Common dietary supplements for weight loss. Am Fam Physician. 2004;70:1731–1738
  5. Fox S, Fallows D. Internet Health Resources. Pew Internet and American Life Project. http://www.pewinternet.org. Accessed January 2008.
  6. Jordan MA, Haywood T. Evaluation of internet websites marketing herbal weight-loss supplements to consumers. J Altern Complement Med. 2007;13:1035–1043
  7. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed January 2008.
  8. Bent S, Tiedt TN, Odden MC, et al. The relative safety of ephedra compared with other herbal products. Ann Intern Med. 2003;138:468–471
  9. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med. 2000;343:1833–1838
  10. Okada S, Rohan PJ, Miller FW. Myopathies following ingestion of special nutritional products. Arthr Rheum. 1996;39:S49
  11. Theoharides TC. Sudden death of a healthy college student related to ephedrine toxicity from a ma huang–containing drink. J Clin Psychopharmacol. 1997;17:437–439
  12. Zaacks SM, Klein L, Tan CD, et al. Hypersensitivity myocarditis associated with ephedra use. J Toxicol Clin Toxicol. 1999;37:485–489
  13. Gardner SF, Franks AM, Gurley BJ, et al. Effect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteers. Am J Cardiol. 2003;91:1510–1513, A1519.
  14. Jordan S, Murty M, Pilon K. Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions. Can Adverse Reaction News. 2004;14:
  15. Jordan S, Murty M, Pilon K. Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions. CMAJ. 2004;171:993–994
  16. Firenzuoli F, Gori L, Galapai C. Adverse reaction to an adrenergic herbal extract (Citrus aurantium). Phytomedicine. 2005;12:247–248
  17. Food and Drug Administration. http://www.fda.gov/oc/initiatives/ephedra/february2004/. Accessed February 2008.
  18. Nykamp DL, Fackih MN, Compton AL. Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Ann Pharmacother. 2004;38:812–816
  19. Nasir JM, Durning SJ, Ferguson M, et al. Exercise-induced syncope associated with QT prolongation and ephedra-free Xenadrine. Mayo Clin Proc. 2004;79:1059–1062
  20. Gange CA, Madias C, Felix-Getzik EM, et al. Variant angina associated with bitter orange in a dietary supplement. Mayo Clin Proc. 2006;81:545–548
  21. Foster S, Duke JA. Eastern/Central Medicinal Plants. New York: Houghton Mifflin Co; 1990;
  22. Kaegi E. Unconventional therapies for cancer: 2. Green tea (The Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative). CMAJ. 1998;158:1033–1035
  23. Sørensen H, Sonne J. A double-masked study of the effects of ginseng on cognitive functions. Curr Ther Res Clin Exp. 1996;57:959–968
  24. Caron MF, Hotsko AL, Robertson S, et al. Electrocardiographic and hemodynamic effects of Panax ginseng. Ann Pharmacother. 2002;36:758–763
  25. McBride BF, Karapanos AK, Krudysz A, et al. Electrocardiographic and hemodynamic effects of a multicomponent dietary supplement containing ephedra and caffeine: a randomized controlled trial. JAMA. 2004;291:216–221
  26. Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care. 1995;18:1373–1375
  27. Armanini D, De Palo CB, Mattarello MJ, et al. Effect of licorice on the reduction of body fat mass in healthy subjects. J Endocrinol Invest. 2003;26:646–650
  28. Böcker D, Breithardt G. [Induction of arrhythmia by licorice abuse]. Z Kardiol. 1991;80:389–391
  29. Bryer-Ash M, Zehnder J, Angelchik P, et al. Torsades de pointes precipitated by a Chinese herbal remedy. Am J Cardiol. 1987;60:1186–1187
  30. Eriksson JW, Carlberg B, Hillorn V. Life-threatening ventricular tachycardia due to liquorice-induced hypokalaemia. J Intern Med. 1999;245:307–310
  31. Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA. 1982;248:1097–1098
  32. Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities—four case reports. Forensic Sci Int. 2004;139:71–73
  33. Andersen T, Fogh J. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. J Hum Nutr Diet. 2001;14:243–250
  34. Cannon ME, Cooke CT, McCarthy JS. Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products. Med J Aust. 2001;174:520–521
  35. Schulz V, Hänsel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. 3d ed. Berlin: Springer; 1998;
  36. Schiffner R, Przybilla B, Burgdorff T, et al. Anaphylaxis to buckwheat. Allergy. 2001;56:1020–1021
  37. Lee SY, Lee KS, Hong CH, et al. Three cases of childhood nocturnal asthma due to buckwheat allergy. Allergy. 2001;56:763–766
  38. Heffler E, Guida G, Badiu I, et al. Anaphylaxis after eating Italian pizza containing buckwheat as the hidden food allergen. J Investig Allergol Clin Immunol. 2007;17:261–263
  39. Noma T, Yoshizawa I, Ogawa N, et al. Fatal buckwheat dependent exercised-induced anaphylaxis. Asian Pac J Allergy Immunol. 2001;19:283–286
  40. Kashima T, Fukui M, Masuda Y, et al. [A case of acute death taking “nyan-mien,” Korean buckwheat noodle]. Nihon Hoigaku Zasshi. 1961;15:391–394

PII: S1547-5271(09)00170-2

doi: 10.1016/j.hrthm.2009.02.021

Heart Rhythm
Volume 6, Issue 5 , Pages 658-662 , May 2009

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