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Heart Rhythm
Volume 6, Issue 5
, Pages 634-641
, May 2009
Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae
References
- . Interatrial conduction in the mechanisms of atrial fibrillation: from anatomy to cardiac signals and new treatment modalities. Europace. 2007;9(Suppl 6):vi10–vi16
- . Significance of QRS complex duration in patients with heart failure. J Am Coll Cardiol. 2005;46:2183–2192
- Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC Med Genet. 2007;8(Suppl 1):S7
- . The atrioventricular conduction time—a heritable trait? III (Twin studies). Clin Genet. 1982;21:181–183
- Variability of heart rate, P-R, QRS and Q-T durations in twins. J Electrocardiol. 1980;13:45–48
- A sodium-channel mutation causes isolated cardiac conduction disease. Nature. 2001;409:1043–1047
- Cardiac conduction defects associate with mutations in SCN5A. Net Genet. 1999;23:20–21
- Common sodium channel promoter haplotype in Asian subjects underlies variability in cardiac conduction. Circulation. 2006;113:338–344
- Heritability of ECG measurements in adult male twins. J Electrocardiol. 1998;30:S64–S68
- Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature. 2007;448:353–357
- A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet. 2006;38:644–651
- Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia. Nat Genet. 2006;38:214–217
- Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia. Hum Hered. 2001;51:8–19
- Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Gen. 2009;5:e1000365
- PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559–575
- . A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics. 2006;22:7–12
- Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–265
- . Inheritance of atrioventricular conduction time in Tokelau Islanders. Clin Genet. 1986;29:56–61
- Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation. 2008;117:1927–1935
- Cardiac sodium channel gene variants and sudden cardiac death in women. Circulation. 2008;117:16–23
- Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest. 2003;112:1019–1028
- Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 1998;392:293–296
- Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA. 2005;293:447–454
- A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. J Mol Cell Cardiol. 2005;38:969–981
- Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging. Circulation. 2005;112:1927–1935
- Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Nat Acad Sci U S A. 2002;99:6210–6215
- Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice. Biochem Biophys Res Commun. 2007;355:444–450
- Mouse model of SCN5A-linked hereditary Lenegre's disease: age-related conduction slowing and myocardial fibrosis. Circulation. 2005;111:1738–1746
- A common polymorphism in SCN5A is associated with lone atrial fibrillation. Clin Pharmacol Ther. 2007;81:35–41
- Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science. 2002;297:1333–1336
- . Heterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig hearts. J Mol Cell Cardiol. 2002;34:1185–1194
- TGF-beta1 induces cardiac hypertrophic responses via PKC-dependent ATF-2 activation. J Mol Cell Cardiol. 2005;39:627–636
- Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc Res. 2008;78:485–493
- Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008;8:75
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661–678
- Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol. 2008;32:381–385
- Phytosterolemia on the island of Kosrae: founder effect for a novel ABCG8 mutation results in high carrier rate and increased plasma plant sterol levels. J Lipid Res. 2004;45:1608–1613
Dr. Newton-Cheh was supported by National Institutes of Health grant no. NIH K23-HL-080025, a Doris Duke Charitable Foundation Clinical Scientist Development Award, and a Burroughs Wellcome Fund Career Award for Medical Scientists. J.K. Lowe was supported by a Tosteson Post-Doctoral Fellowship for Basic Research from the Massachusetts Biomedical Research Corporation. Dr. Altshuler is a Burroughs Wellcome Fund Clinical Scholar in Translational Research and a Distinguished Clinical Scholar of the Doris Duke Charitable Foundation. The genome-wide association scan on Kosrae was supported by grants from the Starr Foundation and Howard Hughes Medical Institute.
PII: S1547-5271(09)00171-4
doi: 10.1016/j.hrthm.2009.02.022
© 2009 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
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Heart Rhythm
Volume 6, Issue 5
, Pages 634-641
, May 2009
