Heart Rhythm
Volume 6, Issue 6 , Pages 796-802 , June 2009

Transmural optical measurements of Vm dynamics during long-duration ventricular fibrillation in canine hearts

  • Wei Kong, PhD

      Affiliations

    • Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama
  • ,
  • Raymond E. Ideker, MD, PhD, FHRS

      Affiliations

    • Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama
    • Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
    • Department of Physiology, University of Alabama at Birmingham, Birmingham, Alabama
  • ,
  • Vladimir G. Fast, PhD

      Affiliations

    • Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Vladimir G. Fast, University of Alabama-Birmingham, 1670 University Boulevard, VH B126, Birmingham, Alabama 35294

Received 11 December 2008 ,Accepted 18 February 2009.

References 

  1. Zheng ZJ, Croft JB, Giles WH, et al. Sudden cardiac death in the United States, 1989 to 1998. Circulation. 2001;104:2158–2163
  2. Nichol G, Stiell IG, Laupacis A, et al. A cumulative meta-analysis of the effectiveness of defibrillator-capable emergency medical services for victims of out-of-hospital cardiac arrest. Ann Emerg Med. 1999;34:517–525
  3. Cummins RO. From concept to standard-of-care? (Review of the clinical experience with automated external defibrillators). Ann Emerg Med. 1989;18:1269–1275
  4. Campbell JP, Kroshus KS, Lindholm DJ, et al. Measuring the call-receipt-to-defibrillation interval: evaluation of prehospital methods. Ann Emerg Med. 1995;26:697–701
  5. Cobb LA, Fahrenbruch CE, Walsh TR, et al. Influence of cardiopulmonary resuscitation prior to defibrillation in patients with out-of-hospital ventricular fibrillation. JAMA. 1999;281:1182–1188
  6. Samie FH, Berenfeld O, Anumonwo J, et al. Rectification of the background potassium current: a determinant of rotor dynamics in ventricular fibrillation. Circ Res. 2001;89:1216–1223
  7. Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998;98:2334–2351
  8. Garfinkel A, Kim YH, Voroshilovsky O, et al. Preventing ventricular fibrillation by flattening cardiac restitution. PNAS. 2000;97:6061–606
  9. Zaitsev AV, Berenfeld O, Mironov SF, et al. Distribution of excitation frequencies on the epicardial and endocardial surfaces of fibrillating ventricular wall of the sheep heart. Circ Res. 2000;86:408–417
  10. Valderrabano M, Lee MH, Ohara T, et al. Dynamics of intramural and transmural reentry during ventricular fibrillation in isolated swine ventricles. Circ Res. 2001;88:839–848
  11. Akar FG, Rosenbaum DS. Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure. Circ Res. 2003;93:638–645
  12. Caldwell BJ, Legrice IJ, Hooks DA, et al. Intramural measurement of transmembrane potential in the isolated pig heart: validation of a novel technique. J Cardiovasc Electrophysiol. 2005;16:1001–1010
  13. Kong W, Fakhari N, Sharifov OF, et al. Optical measurements of intramural action potentials in isolated porcine hearts using optrodes. Heart Rhythm. 2007;4:1430–1436
  14. Fedorov VV, Lozinsky IT, Sosunov EA, et al. Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts. Heart Rhythm. 2007;4:619–626
  15. Newton JC, Huang J, Rogers JM, et al. Pacing during ventricular fibrillation: factors influencing the ability to capture. J Cardiovasc Electrophysiol. 2001;12:76–84
  16. Maier GW, Tyson GS, Olsen CO, et al. The physiology of external cardiac massage: high-impulse cardiopulmonary resuscitation. Circulation. 1984;70:86–101
  17. Gray RA, Jalife J. Effects of atrial defibrillation shocks on the ventricles in isolated sheep hearts. Circulation. 1998;97:1613–1622
  18. Huizar JF, Warren MD, Shvedko AG, et al. Three distinct phases of VF during global ischemia in the isolated blood–perfused pig heart. Am J Physiol. 2007;293:H1617–H1628
  19. Hayashi H, Miyauchi Y, Chou CC, et al. Effects of cytochalasin D on electrical restitution and the dynamics of ventricular fibrillation in isolated rabbit heart. J Cardiovasc Electrophysiol. 2003;14:1077–1084
  20. Allison JS, Qin H, Dosdall DJ, et al. The transmural activation sequence in porcine and canine left ventricle is markedly different during long-duration ventricular fibrillation. J Cardiovasc Electrophysiol. 2007;18:1306–1312
  21. Sicouri S, Quist M, Antzelevitch C. Evidence for the presence of M cells in the guinea pig ventricle. J Cardiovasc Electrophysiol. 1996;7:503–511
  22. Valderrabano M, Chen PS, Lin SF. Spatial distribution of phase singularities in ventricular fibrillation. Circulation. 2003;108:354–359
  23. Wu TJ, Lin SF, Hsieh YC, et al. Ventricular fibrillation during no-flow global ischemia in isolated rabbit hearts. J Cardiovasc Electrophysiol. 2006;17:1112–1120
  24. Mandapati R, Asano Y, Baxter WT, et al. Quantification of effects of global ischemia on dynamics of ventricular fibrillation in isolated rabbit heart. Circulation. 1998;98:1688–1696
  25. Tovar OH, Jones JL. Electrophysiological deterioration during long-duration ventricular fibrillation. Circulation. 2000;102:2886–2891
  26. Worley SJ, Swain JL, Colavita PG, et al. Development of an endocardial-epicardial gradient of activation rate during electrically induced, sustained ventricular fibrillation in dogs. Am J Cardiol. 1985;55:813–820
  27. Cordeiro JM, Greene L, Heilmann C, et al. Transmural heterogeneity of calcium activity and mechanical function in the canine left ventricle. Am J Physiol. 2004;286:H1471–H1479
  28. Gilmour RF, Zipes DP. Different electrophysiological responses of canine endocardium and epicardium to combined hyperkalemia, hypoxia, and acidosis. Circ Res. 1980;46:814–825
  29. Dosdall DJ, Tabereaux PB, Kim JJ, et al. Chemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogs. Am J Physiol. 2008;295:H883–H889
  30. Downar E, Janse MJ, Durrer D. The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart. Circulation. 1977;56:217–224
  31. Huang J, Zhou X, Smith WM, et al. Restitution properties during ventricular fibrillation in the in situ swine heart. Circulation. 2004;110:3161–3167
  32. Cao JM, Qu Z, Kim YH, et al. Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: importance of cardiac restitution properties. Circ Res. 1999;84:1318–1331

 This work was supported by National Institutes of Health grants HL28429, HL85370 and HL67748. The authors thank the Southern Research Institute for providing resources for this study, Dr. Shouluan Ding for help with statistical analysis, and Reuben Collins and Frank Vance for technical support.

PII: S1547-5271(09)00210-0

doi: 10.1016/j.hrthm.2009.02.028

Heart Rhythm
Volume 6, Issue 6 , Pages 796-802 , June 2009