Heart Rhythm
Volume 6, Issue 5 , Pages 632-633 , May 2009

Ajmaline challenge: To stop or not to stop…

  • Vincent Probst, MD, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Vincent Probst, Service de Cardiologie, CHU de Nantes, Hôpital Nord, Bd Jacques Monod, 44093 Nantes Cedex, France
    • ,
  • Herve Le Marec, MD, PhD

References 

  1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome (A multicenter report). J Am Coll Cardiol. 1992;20:1391–1396
  2. Veltmann C, Schimpf R, Echternach C, et al. A prospective study on spontaneous fluctuations between diagnostic and non-diagnostic ECGs in Brugada syndrome: implications for correct phenotyping and risk stratification. Eur Heart J. 2006;27:2544–2552
  3. Brugada R, Brugada J, Antzelevitch C, et al. Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation. 2000;101:510–515
  4. Wilde AA, Antzelevitch C, Borggrefe M, et al. Proposed diagnostic criteria for the Brugada syndrome. Eur Heart J. 2002;23:1648–1654
  5. Antzelevitch C, Brugada P, Borggrefe M, et al. Brugada syndrome: report of the second consensus conference. Heart Rhythm. 2005;2:429–440
  6. Priori SG, Napolitano C, Gasparini M, et al. Natural history of Brugada syndrome: insights for risk stratification and management. Circulation. 2002;105:1342–1347
  7. Eckardt L, Probst V, Smits JP, et al. Long-term prognosis of individuals with right precordial ST-segment-elevation Brugada syndrome. Circulation. 2005;111:257–263
  8. Brugada J, Brugada R, Brugada P. Determinants of sudden cardiac death in individuals with the electrocardiographic pattern of Brugada syndrome and no previous cardiac arrest. Circulation. 2003;108:3092–3096
  9. Gasparini M, Priori SG, Mantica M, et al. Flecainide test in Brugada syndrome: a reproducible but risky tool. Pacing Clin Electrophysiol. 2003;26:338–341
  10. Batchvarov V, Govindan M, Camm AJ, et al. Significance of QRS prolongation during diagnostic ajmaline test in patients with suspected Brugada syndrome. Heart Rhythm. 2009;6:625–631
  11. Antzelevitch C, Brugada P, Brugada J, et al. Brugada syndrome: 1992–2002: a historical perspective. J Am Coll Cardiol. 2003;41:1665–1671
  12. Meregalli PG, Wilde AA, Tan HL. Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?. Cardiovasc Res. 2005;67:367–378
  13. Hermida JS, Denjoy I, Clerc J, et al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol. 2004;43:1853–1860
  14. Sacher F, Probst V, Iesaka Y, et al. Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: a multicenter study. Circulation. 2006;114:2317–2324

PII: S1547-5271(09)00284-7

doi: 10.1016/j.hrthm.2009.03.009

Heart Rhythm
Volume 6, Issue 5 , Pages 632-633 , May 2009

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