Heart Rhythm
Volume 6, Issue 7 , Pages 972-977, July 2009

Echocardiographic study of the optimal atrioventricular delay at rest and during exercise in recipients of cardiac resynchronization therapy systems

  • Bilel Mokrani, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Stephane Lafitte, MD, PhD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Antoine Deplagne, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Sylvain Ploux, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Julien Laborderie, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Patricia Reant, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Pierre Dos Santos, MD, PhD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Raymond Roudaut, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Pierre Jais, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Michel Haissaguerre, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Jacques Clementy, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
  • ,
  • Pierre Bordachar, MD

      Affiliations

    • University Victor Segalen, 33000 Bordeaux, France
    • Hospital Haut Leveque, Pessac, France
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Pierre Bordachar, Hospital Haut Leveque, Service Professor Clementy, Pessac 33604, France

Received 30 October 2008; accepted 12 March 2009. published online 20 March 2009.

Background

It is unclear whether, in recipients of cardiac resynchronization therapy (CRT) systems, the optimal AV delay should be the same, shorter, or longer during exercise than at rest.

Objective

This study sought to examine the effects of atrioventricular (AV) delay optimization at rest and during exercise in 50 recipients of CRT systems.

Methods

We measured left ventricular (LV) outflow tract velocity time integral (OT-VTI) and LV filling time (FT) echocardiographically, at rest and during exercise to 60% of the maximal predicted heart rate, with the sensed AV delay set at 40, 70, 100, 120, 150, and 200 ms. The measurements made at rest versus those made during exercise, and among the several programmed AV delays, were compared.

Results

The optimal AV delay based on LVOT-VTI was shorter during exercise than at rest in 37%, unchanged in 37%, and longer in 26% of patients. The optimal AV delay based on LVFT was shorter during exercise than at rest in 27%, unchanged in 23%, and longer in 50% of patients. Optimization of the AV delay during exercise increased LVFT and LVOT-VTI significantly (P < .05) compared with (1) any other arbitrarily chosen AV delay, (2) the optimal AV delay at rest, (3) an AV delay systematically shortened from rest to exercise.

Conclusion

Optimization of the AV delay had a positive effect on echocardiographic indices of LV function. The systematic shortening of the AV delay during exercise is not recommended because, in a high proportion of patients, the optimal AV delay was longer during exercise than at rest.

Keywords: Cardiac resynchronization therapy, Atrioventricular delay, Rate-responsive pacing, Ventricular filling time, Velocity time integral, Exercise echocardiography

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PII: S1547-5271(09)00314-2

doi:10.1016/j.hrthm.2009.03.023

Heart Rhythm
Volume 6, Issue 7 , Pages 972-977, July 2009