Heart Rhythm
Volume 6, Issue 7 , Pages 1035-1037 , July 2009

Are electrophysiologically distinct M-cells a characteristic of the wedge preparation?

  • Steven Poelzing, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Steven Poelzing, University of Utah, Nora Eccles Harrison CVRTI, 95 South 2000 East, Salt Lake City, Utah 84112-5000

References 

  1. Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS. Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome. Circulation. 2002;105:1247–1253
  2. Fish JM, Di Diego JM, Nesterenko V, Antzelevitch C. Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing. Circulation. 2004;109:2136–2142
  3. Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 199;100:1660–1666.
  4. Akar FG, Rosenbaum DS. Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure. Circ Res. 2003;93:638–645
  5. Voss F, Opthof O, Marker J, Bauer A, Katus H, Becker R. There is no transmural heterogeneity in an index of action potential duration in the canine left ventricle. Heart Rhythm. 2009;6:1028–1034
  6. Liu DW, Antzelevitch C. Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell. Circ Res. 1995;76:351–365
  7. Antzelevitch C. The M cell. J Cardiovasc Pharmacol Ther. 1997;2:73–76
  8. Zygmunt AC, Goodrow RJ, Weigel CM. INaCa and ICl(Ca) contribute to isoproterenol-induced delayed after depolarizations in midmyocardial cells. Am J Physiol. 1998;275:H1979–H1992
  9. Zygmunt AC, Eddlestone GT, Thomas GP, Nesterenko VV, Antzelevitch C. Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle. Am J Physiol Heart Circ Physiol. 2001;281:H689–H697
  10. Sicouri S, Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle (The M cell). Circ Res. 1991;68:1729–1741
  11. Yan GX, Shimizu W, Antzelevitch C. Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations. Circulation. 1998;98:1921–1927
  12. Poelzing S, Akar FG, Baron E, Rosenbaum DS. Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol. 2004;286:H2001–H2009
  13. Weissenburger J, Nesterenko VV, Antzelevitch C. Transmural heterogeneity of ventricular repolarization under baseline and long QT conditions in the canine heart in vivo: torsades de pointes develops with halothane but not pentobarbital anesthesia. J Cardiovasc Electrophysiol. 2000;11:290–304
  14. Haws CW, Lux RL. Correlation between in vivo transmembrane action potential durations and activation-recovery intervals from electrograms (Effects of interventions that alter repolarization time). Circulation. 1990;81:281–288
  15. Millar CK, Kralios FA, Lux RL. Correlation between refractory periods and activation-recovery intervals from electrograms: effects of rate and adrenergic interventions. Circulation. 1985;72:1372–1379
  16. El-Sherif N, Caref EB, Yin H, Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome (Tridimensional mapping of activation and recovery patterns). Circ Res. 1996;79:474–492
  17. Ueda N, Zipes DP, Wu J. Functional and transmural modulation of M cell behavior in canine ventricular wall. Am J Physiol Heart Circ Physiol. 2004;287:H2569–H2575
  18. Morita ST, Zipes DP, Morita H, Wu J. Analysis of action potentials in the canine ventricular septum: no phenotypic expression of M cells. Cardiovasc Res. 2007;74:96–103

PII: S1547-5271(09)00409-3

doi: 10.1016/j.hrthm.2009.04.012

Heart Rhythm
Volume 6, Issue 7 , Pages 1035-1037 , July 2009

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