Heart Rhythm
Volume 6, Issue 9 , Pages 1335-1341 , September 2009

Drugs and Brugada syndrome patients: Review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)

  • Pieter G. Postema, MD

      Affiliations

    • Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Pieter G. Postema or Dr. Arthur A. M. Wilde, Department of Cardiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    • ,
  • Christian Wolpert, MD

      Affiliations

    • 1st Department of Medicine-Cardiology, University Hospital Mannheim, Mannheim, Germany
    • ,
  • Ahmad S. Amin, MD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Vincent Probst, MD, PhD

      Affiliations

    • L'Institut du Thorax, Service de Cardiologie du CHU de Nantes and INSERM UMR 915, Université de Nantes, Nantes, France
    • ,
  • Martin Borggrefe, MD, PhD

      Affiliations

    • 1st Department of Medicine-Cardiology, University Hospital Mannheim, Mannheim, Germany
    • ,
  • Dan M. Roden, MD

      Affiliations

    • Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee
    • ,
  • Silvia G. Priori, MD, PhD

      Affiliations

    • Molecular Cardiology, Fondazione Salvatore Maugeri, Department of Cardiology, University of Pavia, Pavia, Italy
    • ,
  • Hanno L. Tan, MD, PhD

      Affiliations

    • Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Masayasu Hiraoka, MD, PhD

      Affiliations

    • Department of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    • ,
  • Josep Brugada, MD, PhD

      Affiliations

    • Arrhythmia Section, Cardiovascular Institute, Hospital Clínic, University of Barcelona, Barcelona, Spain
    • ,
  • Arthur A.M. Wilde, MD, PhD

      Affiliations

    • Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Pieter G. Postema or Dr. Arthur A. M. Wilde, Department of Cardiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands

Received 26 June 2009 ,Accepted 3 July 2009.

  • Image Result

    Conversion of a normal ECG to a type 1 Brugada syndrome ECG during ajmaline challenge. Note the coved-type ST segments (arrows) in the right precordial ECG leads at peak ajmaline (note that V3 is plac

    Conversion of a normal ECG to a type 1 Brugada syndrome ECG during ajmaline challenge. Note the coved-type ST segments (arrows) in the right precordial ECG leads at peak ajmaline (note that V3 is placed in the third intercostal space above V1 [V1ic3], and V5 is placed in the third intercostal space above V2 [V2ic3]).

  • Image Result
    Nonsustained ventricular tachycardia in a patient who was given flecainide for paroxysmal atrial fibrillation. Note the coved-type ST segments (arrow). The patient was diagnosed with Brugada syndrome

    Nonsustained ventricular tachycardia in a patient who was given flecainide for paroxysmal atrial fibrillation. Note the coved-type ST segments (arrow). The patient was diagnosed with Brugada syndrome during an ajmaline provocation test.

  • Image Result
    Screenshot of the website www.brugadadrugs.org.

    Screenshot of the website www.brugadadrugs.org.

 This study was supported by The Netherlands Heart Foundation Grant 2005T024 to Dr. Postema; Fondation Leducq Trans-Atlantic Network of Excellence, Preventing Sudden Death Grant 05-CVD-01 to Dr. Wilde; CHU de Nantes, France, and Société Française de Cardiologie Grant P.H.R.C. 2004 R20/07 to Dr. Probst; and National Institutes of Health Grant HL65962 to Dr. Roden.

PII: S1547-5271(09)00739-5

doi: 10.1016/j.hrthm.2009.07.002

Heart Rhythm
Volume 6, Issue 9 , Pages 1335-1341 , September 2009

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