Heart Rhythm
Volume 6, Issue 10 , Pages 1423-1424 , October 2009

Mechanisms of postcardiac surgery atrial fibrillation: More pieces in a difficult puzzle

  • Antony J. Workman, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Antony J. Workman, British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular & Medical Sciences, Faculty of Medicine, University of Glasgow, 126 University Place, Glasgow G12 8TA, United Kingdom

References 

  1. Mathew JP, Fontes ML, Tudor IC, et al. A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA. 2004;291:1720–1729
  2. Workman AJ, Kane KA, Rankin AC. Cellular bases for human atrial fibrillation. Heart Rhythm. 2008;5:S1–S6
  3. Sanders P, Berenfeld O, Hocini M, et al. Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans. Circulation. 2005;112:789–797
  4. Sarmast F, Kolli A, Zaitsev A, et al. Cholinergic atrial fibrillation: IK,ACh gradients determine unequal left/right atrial frequencies and rotor dynamics. Cardiovasc Res. 2003;59:863–873
  5. Passman R, Beshai J, Pavri B, et al. Predicting post-coronary bypass surgery atrial arrhythmias from the preoperative electrocardiogram. Am Heart J. 2001;142:806–810
  6. Dobrev D, Wettwer E, Kortner A, et al. Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation. Cardiovasc Res. 2002;54:397–404
  7. Workman AJ, Pau D, Redpath CJ, et al. Post-operative atrial fibrillation is influenced by beta-blocker therapy but not by pre-operative atrial cellular electrophysiology. J Cardiovasc Electrophysiol. 2006;17:1230–1238
  8. Tanaka K, Zlochiver S, Vikstrom KL, et al. Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure. Circ Res. 2007;101:839–847
  9. Cosgrave J, Foley JB, Flavin R, et al. Preoperative atrial histological changes are not associated with postoperative atrial fibrillation. Cardiovasc Pathol. 2006;15:213–217
  10. Swartz MF, Fink GW, Lutz CJ, et al. Left-versus-right atrial difference in dominant frequency, K+ channel transcripts, and fibrosis in patients developing atrial fibrillation following cardiac surgery. Heart Rhythm. 2009;6:1415–1422
  11. Pandit SV, Berenfeld O, Anumonwo JMB, et al. Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophys J. 2005;88:3806–3821
  12. Workman AJ, Kane KA, Rankin AC. The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovasc Res. 2001;52:226–235
  13. Workman AJ, Pau D, Redpath CJ, et al. Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF. Heart Rhythm. 2009;6:445–451

PII: S1547-5271(09)00802-9

doi: 10.1016/j.hrthm.2009.07.031

Heart Rhythm
Volume 6, Issue 10 , Pages 1423-1424 , October 2009

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