Heart Rhythm
Volume 7, Issue 2 , Pages 238-248 , February 2010

Mechanism of right precordial ST-segment elevation in structural heart disease: Excitation failure by current-to-load mismatch

  • Mark G. Hoogendijk, MD,

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Mark G. Hoogendijk, Heart Failure Research Center, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    • ,
  • Mark Potse, PhD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Research Center, Sacré-Coeur Hospital, Université de Montréal, Montreal, Quebec, Canada
    • Institute of Biomedical Engineering, Université de Montréal, Montreal, Quebec, Canada
    • Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands
    • ,
  • André C. Linnenbank, PhD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands
    • ,
  • Arie O. Verkerk, PhD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Hester M. den Ruijter, PhD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Shirley C.M. van Amersfoorth, MSc

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Eva C. Klaver, MB

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Leander Beekman, BSc

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Connie R. Bezzina, PhD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Pieter G. Postema, MD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Hanno L. Tan, MD, PhD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Annette G. Reimer, MD, PhD

      Affiliations

    • Children's Heart Center, University Medical Center St. Radboud, Nijmegen, The Netherlands
    • ,
  • Allard C. van der Wal, MD, PhD

      Affiliations

    • Department of Cardiovascular Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Arend D.J. ten Harkel, MD, PhD

      Affiliations

    • Department of Pediatric Cardiology, Thoraxcenter and Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Michiel Dalinghaus, MD, PhD

      Affiliations

    • Department of Pediatric Cardiology, Thoraxcenter and Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Alain Vinet, PhD

      Affiliations

    • Research Center, Sacré-Coeur Hospital, Université de Montréal, Montreal, Quebec, Canada
    • Institute of Biomedical Engineering, Université de Montréal, Montreal, Quebec, Canada
    • ,
  • Arthur A.M. Wilde, MD, PhD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Jacques M.T. de Bakker, PhD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands
    • ,
  • Ruben Coronel, MD, PhD

      Affiliations

    • Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Received 2 June 2009 ,Accepted 5 October 2009.

References 

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 The first two authors contributed equally to this work. This study was supported by The Netherlands Heart Foundation Grant 2005T024 to Dr. Bezzina, Grant 2003T302 to Dr. Wilde, Grant 2005B092 to Drs. de Bakker and Linnenbank, and Grant 2008B062 to Dr. Coronel; the Interuniversity Cardiology Institute of The Netherlands; the Royal Netherlands Academy of Arts and Sciences to Dr. Tan; the Netherlands Organisation for Scientific Research Grant ZonMW-VICI 918.86.616 to Dr. Tan; and the Réseau Québécois de Calcul de Haute Performance (RQCHP).

PII: S1547-5271(09)01151-5

doi: 10.1016/j.hrthm.2009.10.007

Heart Rhythm
Volume 7, Issue 2 , Pages 238-248 , February 2010

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