Heart Rhythm
Volume 7, Issue 2 , Pages 199-205, February 2010

KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders

  • Jie Wu, PhD

      Affiliations

    • Pharmacology Department, Medical School of Xi'an Jiaotong University. Xi'an, Shaanxi, China
    • ,
  • Wataru Shimizu, MD, PhD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    • ,
  • Wei-Guang Ding, MD, PhD

      Affiliations

    • Department of Physiology, Shiga University of Medical Science, Ohtsu, Japan
    • ,
  • Seiko Ohno, MD, PhD

      Affiliations

    • Department of Cardiovascular Medicine, Kyoto University of Graduate School of Medicine, Kyoto, Japan
    • ,
  • Futoshi Toyoda, PhD

      Affiliations

    • Department of Physiology, Shiga University of Medical Science, Ohtsu, Japan
    • ,
  • Hideki Itoh, MD, PhD

      Affiliations

    • Department of Cardiovascular Medicine, Shiga University of Medical Science, Shiga, Japan
    • ,
  • Wei-Jin Zang, MD, PhD

      Affiliations

    • Pharmacology Department, Medical School of Xi'an Jiaotong University. Xi'an, Shaanxi, China
    • ,
  • Yoshihiro Miyamoto, MD, PhD

      Affiliations

    • Laboratory of Molecular Genetics, National Cardiovascular Center, Suita, Japan
    • ,
  • Shiro Kamakura, MD, PhD

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    • ,
  • Hiroshi Matsuura, MD, PhD

      Affiliations

    • Department of Physiology, Shiga University of Medical Science, Ohtsu, Japan
    • ,
  • Koonlawee Nademanee, MD, FACC

      Affiliations

    • Department of Medicine (Cardiology), University of Southern California, Los Angeles, California
    • ,
  • Josep Brugada, MD

      Affiliations

    • Cardiovascular Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain
    • ,
  • Pedro Brugada, MD

      Affiliations

    • Heart Rhythm Management Centre, Free University of Brussels (UZ Brussel) VUB, Brussels, Belgium
    • ,
  • Ramon Brugada, MD, PhD, FACC

      Affiliations

    • School of Medicine, Cardiovascular Genetics Center, University of Girona, Girona, Spain
    • ,
  • Matteo Vatta, PhD

      Affiliations

    • Departments of Pediatrics, Baylor College of Medicine, Houston, Texas
    • Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas
    • ,
  • Jeffrey A. Towbin, MD, FAAP, FACC

      Affiliations

    • Departments of Pediatrics, Baylor College of Medicine, Houston, Texas
    • ,
  • Charles Antzelevitch, PhD, FACC, FAHA, FHRS

      Affiliations

    • Masonic Medical Research Laboratory, Utica, New York
    • ,
  • Minoru Horie, MD, PhD

      Affiliations

    • Department of Cardiovascular Medicine, Shiga University of Medical Science, Shiga, Japan
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Minoru Horie, Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan

Received 20 August 2009; accepted 7 October 2009. published online 12 October 2009.

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 The first two authors contributed equally to the original concept and the authorship of this study. This study was supported by grants from the Ministry of Education, Culture, Sports, Science, Technology Leading Project for Biosimulation to Dr. Horie; Health Sciences Research grants (H18-Research on Human Genome-002) from the Ministry of Health, Labour and Welfare, Japan to Drs. Shimizu and Horie; the National Natural Science Foundation of China (Key Program, No.30930105; General Program, No. 30873058, 30770785) and the National Basic Research Program of China (973 Program, No. 2007CB512005) and CMB Distinguished Professorships Award (No. F510000/G16916404) to Dr. Zang; and National Institutes of Health Grant HL47678 and Free and Accepted Masons of New York State and Florida to Dr. Antzelevitch.

PII: S1547-5271(09)01156-4

doi:10.1016/j.hrthm.2009.10.012

Heart Rhythm
Volume 7, Issue 2 , Pages 199-205, February 2010

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