Heart Rhythm
Volume 7, Issue 2 , Pages 206-207 , February 2010

Cardiac Ito, KCNE2, and Brugada syndrome: Promiscuous subunit interactions, or what happens in HEK cells stays in HEK cells?

  • Gordon F. Tomaselli, MD, FHRS

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Gordon F. Tomaselli, 720 N. Rutland Ave Ross 844, Johns Hopkins University, School of Medicine, Baltimore, MD 21205

References 

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  3. Sesti F, Abbott GW, Wei J, et al. A common polymorphism associated with antibiotic-induced cardiac arrhythmia. Proc Natl Acad Sci U S A. 2000;97:10613–10618
  4. Scicluna BP, Wilde AA, Bezzina CR. The primary arrhythmia syndromes: same mutation, different manifestations (Are we starting to understand why?). J Cardiovasc Electrophysiol. 2008;19:445–452
  5. Bezzina C, Veldkamp MW, van Den Berg MP, et al. A single Na(+) channel mutation causing both long-QT and Brugada syndromes. Circ Res. 1999;85:1206–1213
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  13. Pourrier M, Schram G, Nattel S. Properties, expression and potential roles of cardiac K+ channel accessory subunits: MinK, MiRPs, KChIP, and KChAP. J Membr Biol. 2003;194:141–152
  14. Deschenes I, Tomaselli GF. Modulation of Kv4.3 current by accessory subunits. FEBS Lett. 2002;528:183–188
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  16. Radicke S, Cotella D, Graf EM, et al. Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Cardiovasc Res. 2006;71:695–703
  17. Decher N, Barth AS, Gonzalez T, Steinmeyer K, Sanguinetti MC. Novel KChIP2 isoforms increase functional diversity of transient outward potassium currents. J Physiol. 2004;557:761–772
  18. Zhang M, Jiang M, Tseng GN. minK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel?. Circ Res. 2001;88:1012–1019
  19. Tinel N, Diochot S, Borsotto M, Lazdunski M, Barhanin J. KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J. 2000;19:6326–6330
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PII: S1547-5271(09)01204-1

doi: 10.1016/j.hrthm.2009.10.029

Heart Rhythm
Volume 7, Issue 2 , Pages 206-207 , February 2010

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