Heart Rhythm
Volume 7, Issue 7 , Pages 876-882 , July 2010

Gender differences in clinical outcome and primary prevention defibrillator benefit in patients with severe left ventricular dysfunction: A systematic review and meta-analysis

  • Pasquale Santangeli, MD

      Affiliations

    • Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Pasquale Santangeli, Cardiology Department, Catholic University, Largo A. Gemelli 8, 00168 Rome, Italy
    • ,
  • Gemma Pelargonio, MD, PhD

      Affiliations

    • Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Antonio Dello Russo, MD, PhD

      Affiliations

    • Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Michela Casella, MD, PhD

      Affiliations

    • Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Caterina Bisceglia, MD

      Affiliations

    • Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Stefano Bartoletti, MD

      Affiliations

    • Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Pietro Santarelli, MD

      Affiliations

    • Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    • ,
  • Luigi Di Biase, MD

      Affiliations

    • Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    • Department of Cardiology, University of Foggia, Foggia, Italy
    • Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas
    • ,
  • Andrea Natale, MD, FHRS

      Affiliations

    • Department of Biomedical Engineering, University of Texas, Austin, Texas
    • Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas

Received 28 December 2009 ,Accepted 31 March 2010.

  • Image Result

    Selection process of studies included in the meta-analysis.

    Selection process of studies included in the meta-analysis.

  • Image Result

    Forest plot showing adjusted hazard ratio of overall mortality (whole study population) (A) and appropriate implantable cardioverter-defibrillator (ICD) intervention (B) in women compared to men in ea

    Forest plot showing adjusted hazard ratio of overall mortality (whole study population) (A) and appropriate implantable cardioverter-defibrillator (ICD) intervention (B) in women compared to men in each study and the overall adjusted hazard ratio. Square boxes denote hazard ratio; horizontal lines represent 95% confidence interval (CI).

  • Image Result
    Forest plot showing hazard ratio of survival benefit associated with implantable cardioverter-defibrillator (ICD) use in women (A) and in men (B) in each study and the overall hazard ratio. Square box

    Forest plot showing hazard ratio of survival benefit associated with implantable cardioverter-defibrillator (ICD) use in women (A) and in men (B) in each study and the overall hazard ratio. Square boxes denote hazard ratio; horizontal lines represent 95% confidence interval (CI). In SCD-HeFT, placebo denotes the no-amiodarone group; in COMPANION, placebo denotes the standard medical therapy group (no cardiac resynchronization therapy).

 Dr. Natale has received compensation for belonging to the speakers' bureau for St. Jude Medical, Boston Scientific, Medtronic, and Biosense Webster and has received a research grant from St. Jude Medical.

PII: S1547-5271(10)00336-X

doi: 10.1016/j.hrthm.2010.03.042

Heart Rhythm
Volume 7, Issue 7 , Pages 876-882 , July 2010

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