Heart Rhythm
Volume 7, Issue 8 , Pages 1104-1110 , August 2010

Cardiac expression of skeletal muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial infarction

  • Ruben Coronel, MD, PhD

      Affiliations

    • Experimental Cardiology Group, Center for Heart Failure Research, Academic Medical Center, Amsterdam, The Netherlands
    • Corresponding Author InformationAddress reprint requests and correspondence: Ruben Coronel, M.D., Ph.D., Experimental Cardiology Group, Center for Heart Failure Research, Academic Medical Center, K2-112, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    • ,
  • David H. Lau, MD, PhD

      Affiliations

    • Department of Medicine, Columbia University Medical Center, New York
    • ,
  • Eugene A. Sosunov, PhD

      Affiliations

    • Department of Pharmacology, Columbia University Medical Center, New York
    • ,
  • Michiel J. Janse, MD, PhD

      Affiliations

    • Experimental Cardiology Group, Center for Heart Failure Research, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • Peter Danilo Jr., PhD

      Affiliations

    • Department of Pharmacology, Columbia University Medical Center, New York
    • Center for Molecular Therapeutics, Columbia University Medical Center, New York
    • ,
  • Evgeny P. Anyukhovsky, PhD

      Affiliations

    • Department of Pharmacology, Columbia University Medical Center, New York
    • ,
  • Francien J.G. Wilms-Schopman

      Affiliations

    • Experimental Cardiology Group, Center for Heart Failure Research, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • Tobias Opthof, PhD

      Affiliations

    • Experimental Cardiology Group, Center for Heart Failure Research, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • Iryna N. Shlapakova, MD

      Affiliations

    • Department of Pharmacology, Columbia University Medical Center, New York
    • ,
  • Nazira Ozgen, MD, PhD

      Affiliations

    • Department of Pharmacology, Columbia University Medical Center, New York
    • ,
  • Kevin Prestia, DVM

      Affiliations

    • Institute for Comparative Medicine, Columbia University Medical Center, New York
    • ,
  • Yelena Kryukova, PhD

      Affiliations

    • Department of Pharmacology, Columbia University Medical Center, New York
    • ,
  • Ira S. Cohen, MD, PhD

      Affiliations

    • Department of Physiology and Biophysics, Stonybrook University, Stonybrook, New York
    • ,
  • Richard B. Robinson, PhD

      Affiliations

    • Department of Pharmacology, Columbia University Medical Center, New York
    • Center for Molecular Therapeutics, Columbia University Medical Center, New York
    • ,
  • Michael R. Rosen, MD

      Affiliations

    • Department of Pharmacology, Columbia University Medical Center, New York
    • Center for Molecular Therapeutics, Columbia University Medical Center, New York
    • Department of Pediatrics, Columbia University Medical Center, New York, New York

Received 7 December 2009 ,Accepted 2 April 2010.

References 

  1. Janse MJ, Wit AL. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol Rev. 1989;69:1049–1169
  2. Wit AL, Janse MJ. Experimental models of ventricular tachycardia and fibrillation caused by ischemia and infarction. Circulation. 1992;85(suppl):I-32–I-42
  3. Mines GR. On circulating excitations in heart muscles and their possible relation to tachycardia and fibrillation. Trans Royal Soc Canada. 1914;4:43–53
  4. Working Group on Arrhythmias of the European Society of Cardiology. The Sicilian gambit (A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms). Circulation. 1991;84:1831–1851
  5. Schmitt FO, Erlanger J. Directional differences in the conduction of the impulse through heart muscle and their possible relation to extrasystolic amd fibrillary contractions. Am J Physiol. 1928;87:326–347
  6. Wit AL, Allessie MA, Fenoglio JJ, Bonke FIM, Lammers WJEP, Smeets JLRM. Significance of the endocardial and epicardial border zones in the genesis of myocardial infarction arrhythmias. In:  Harrison DC,  Hall GK editor. Cardiac Arrhythmias: A decade of progress. Boston: Medical Publishers; 1981;p. 39–68
  7. Ursell PC, Gardner PI, Albala A, Fenoglio JJ, Wit AL. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ Res. 1985;56:436–451
  8. Denniss AR, Richards DA, Waywood JA, et al. Electrophysiological and anatomic differences between canine hearts with inducible ventricular tachycardia and fibrillation associated with chronic myocardial infarction. Circ Res. 1989;64:155–166
  9. Hunt GB, Ross DL. Influence of infarct age on reproducibility of ventricular tachycardia induction in a canine model. J Am Coll Cardiol. 1989;14:765–773
  10. Hayward LJ, Brown RH, Cannon SC. Inactivation defects caused by monotonia-associated mutations in the sodium III-IV linker. J Gen Physiol. 1996;107:559–576
  11. Lau DH, Clausen C, Sosunov EA, et al. Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study. Circulation. 2009;119:19–27
  12. Potse M, Linnenbank AC, Grimbergen CA. Software design for analysis of multichannel intracardial and body surface electrocardiograms. Comp Meth Prog Biomed. 2002;69:225–236
  13. Kleber AG, Janse MJ, Wilms-Schopman FJG, Wilde AAM, Coronel R. Changes in conduction velocity during acute ischemia in ventricular myocardial isolated porcine heart. Circulation. 1986;73:189–198
  14. Coronel R, Wilms-Schopman FJG, de Groot JR, et al. Laplacian electrograms and the interpretation of complex ventricular activation patterns during ventricular fibrillation. J Cardiovasc Electrophysiol. 2000;1119–1128
  15. Sosunov EA, Ayukhovsky EP, Rosen MR. Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium (I. In vitro study). Circulation. 1997;96:4011–4018
  16. Zimmer T, Biskup C, Dugarmaa S, et al. Functional expression of GFP-linked human heart sodium channel (hH1) and subcellular localization of the a subunit in HEK293 cells and dog cardiac myocytes. J Memb Biol. 2002;186:1–12
  17. Malhotra JD, Chen C, Rivolta I, et al. Characterization of sodium channel {{alpha}}- and {beta}-subunits in rat and mouse cardiac myocytes. Circulation. 2001;103:1303–1310
  18. Cohen SA. Immunocytochemical localization of rH1 sodium channel in adult rat heart atria and ventricle: presence in terminal intercalated disks. Circulation. 1996;94:3083–3086
  19. Zimmer T, Bollensdorff C, Haufe V, Birch-Hirschfeld E, Benndorf K. Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants. AJP Heart Circ Physiol. 2002;282:H1007–H1017
  20. Kucera JP, Rohr S, Rudy Y. Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ Res. 2002;91:1176–1182
  21. Wiegerinck RF, De Bakker JMT, Opthof T, et al. The effect of enhanced gap junctional conductance on ventricular conduction in explanted hearts from patients with heart failure. Basic Res Cardiol. 2009;104:321–332
  22. Ciaccio EJ. Localization of the slow conduction zone during reentrant ventricular tachycardia. Circulation. 2000;102:464–469
  23. Ciaccio EJ, Ashikaga H, Kaba RA, et al. Model of reentrant ventricular tachycardia based upon infarct border zone geometry predicts reentrant circuit features as determined by activation mapping. Heart Rhythm. 2007;4:1034–1045

 This study was supported by National Heart, Lung and Blood Institute grant no. HL094410 and by the Stichting Cardiovascular Research (to MJ, TO, RC).

PII: S1547-5271(10)00345-0

doi: 10.1016/j.hrthm.2010.04.009

Heart Rhythm
Volume 7, Issue 8 , Pages 1104-1110 , August 2010

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