Heart Rhythm
Volume 7, Issue 8 , Pages 1102-1103 , August 2010

Action potential voltage alternans: An indicator of calcium handling dysfunction during heart failure?

  • David J. Christini, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. David J. Christini, Greenberg Division of Cardiology, Weill Cornell Medical College, 1300 York Avenue, Box 161, New York, New York 10065

References 

  1. Narayan SM. T-Wave Alternans and the susceptibility to ventricular arrhythmias. J Am Coll Cardiol. 2006;47:269–281
  2. Chinushi M, Restivo M, Caref EB, El-Sherif N. Electrophysiological basis of arrhythmogenicity of QT/T alternans in the long QT syndrome: tridimensional analysis of the kinetics of cardiac repolarization. Circ Res. 1998;83:614–628
  3. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS. Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation. 1999;99:1385–1394
  4. Shimizu W, Antzelevitch C. Cellular and ionic basis for T-wave alternans under long-QT conditions. Circulation. 1999;99:1499–1507
  5. Pastore JM, Rosenbaum DS. Role of structural barriers in the mechanism of alternans-induced reentry. Circ Res. 2000;87:1157–1163
  6. Chow T, Kereiakes DJ, Onufer J, Woelfel A, Gursoy S, Peterson BJ, et al. Does microvolt T-wave alternans testing predict ventricular tachyarrhythmias in patients with ischemic cardiomyopathy and prophylactic defibrillators? (The MASTER (Microvolt T wave alternans testing for risk stratification of post-myocardial infarction patients) trial). J Am Coll Cardiol. 2008;52:1607–1615
  7. Gold M, Ip J, Costantini O, Poole J, Mcnulty S, Mark D, et al. Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction (Primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy). Circulation. 2008;118:2022–2028
  8. Walker ML, Rosenbaum DS. Repolarization alternans: implications for the mechanism and prevention of sudden cardiac death. Cardiovasc Res. 2003;57:599–614
  9. Karma A. Electrical alternans and spiral wave breakup in cardiac tissue. Chaos. 1994;4:461–472
  10. Koller ML, Riccio ML, Gilmour RF. Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation. Am J Physiol. 1998;275:H1635–H1642
  11. Watanabe MA, Fenton FH, Evans SJ, Hastings HM, Karma A. Mechanisms for discordant alternans. J Cardiovasc Electrophysiol. 2001;12:196–206
  12. Fox JJ, McHarg JL, Gilmour RF. Ionic mechanism of electrical alternans. Am J Physiol. 2002;282:H516–H530
  13. Hirayama Y, Saitoh H, Atarashi H, Hayakawa H. Electrical and mechanical alternans in canine myocardium in vivo (Dependence on intracellular calcium cycling). Circulation. 1993;88:2894–2902
  14. Chudin E, Goldhaber J, Garfinkel A, Weiss J, Kogan B. Intracellular Ca2+ dynamics and the stability of ventricular tachycardia. Biophys J. 1999;77:2930–2941
  15. Huser J, Wang YG, Sheehan KA, Cifuentes F, Lipsius SL, Blatter LA. Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells. J Physiol. 2000;524:795–806
  16. Diaz ME, O'Neill SC, Eisner DA. Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternans. Circ Res. 2004;94:650–656
  17. Pruvot EJ, Katra RP, Rosenbaum DS, Laurita KR. Role of calcium cycling versus restitution in the mechanism of repolarization alternans. Circ Res. 2004;94:1083–1090
  18. Goldhaber JI, Xie LH, Duong T, Motter C, Khuu K, Weiss JN. Action potential duration restitution and alternans in rabbit ventricular myocytes the key role of intracellular calcium cycling. Circ Res. 2004;96:459–466
  19. Wan X, Laurita KR, Pruvot EJ, Rosenbaum DS. Molecular correlates of repolarization alternans in cardiac myocytes. J Mol Cell Cardiol. 2005;39:419–428
  20. Bien H, Yin L, Entcheva E. Calcium instabilities in mammalian cardiomyocyte networks. Biophys J. 2006;90:2628–2640
  21. Hayashi H, Shiferaw Y, Sato D, et al. Dynamic origin of spatially discordant alternans in cardiac tissue. Biophys J. 2007;92:448–460
  22. Jordan PN, Christini DJ. Characterizing the contribution of voltage-and calcium-dependent coupling to action potential stability: implications for repolarization alternans. Am J Physiol. 2007;293:H2109–H2118
  23. Li M, Otani NF. Ion channel basis for alternans and memory in cardiac myocytes. Ann Biomed Eng. 2003;31:1213–1230
  24. Xie LH, Sato D, Garfinkel A, Qu Z, Weiss JN. Intracellular Ca alternans: coordinated regulation by sarcoplasmic reticulum release, uptake, and leak. Biophys J. 2008;95:3100–3110
  25. Gaeta SA, Bub G, Abbott GW, Christini DJ. Dynamical mechanism for subcellular alternans in cardiac myocytes. Circ Res. 2009;105:335–342
  26. Aistrup GL, Shiferaw Y, Kapur S, Kadish AH, Wasserstrom JA. Mechanisms underlying the formation and dynamics of subcellular calcium alternans in the intact rat heart. Circ Res. 2009;104:639–649
  27. Shiferaw Y, Watanabe MA, Garfinkel A, Weiss JN, Karma A. Model of intracellular calcium cycling in ventricular myocytes. Biophys J. 2003;85:3666–3686
  28. Picht E, DeSantiago J, Blatter LA, Bers DM. Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res. 2006;99:740–748
  29. Restrepo J, Weiss J, Karma A. Calsequestrin mediated mechanism for cellular calcium transient alternans. Biophys J. 2008;95:3767–3789
  30. Klingenheben T, Ptaszynski P, Hohnloser S. Quantitative assessment of microvolt T-wave alternans in patients with congestive heart failure. J Cardiovasc Electrophysiol. 2005;16:620–624
  31. Narayan SM, Bayer JD, Lalani G, Trayanova NA. Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handling. J Am Coll Cardiol. 2008;52:1782–1792
  32. Laurita KR, Rosenbaum DS. Mechanisms and potential therapeutic targets for ventricular arrhythmias associated with impaired cardiac calcium cycling. J Mol Cell Cardiol. 2008;44:31–43
  33. Bayer JD, Narayan SM, Lalani GG, Trayanova NA. Rate-dependent action potential alternans in human heart failure implicate abnormal intracellular calcium handling. Heart Rhythm. 2010;7:1093–1101
  34. Hasenfuss G, Meyer M, Schillinger W, Preuss M, Pieske B, Just H. Calcium handling proteins in the failing human heart. Basic Res Cardiol. 1997;92(Suppl 1):87–93
  35. Tomaselli GF, Marban E. Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res. 1999;42:270–283
  36. Schmidt U, Hajjar RJ, Kim CS, Lebeche D, Doye AA, Gwathmey JK. Human heart failure: camp stimulation of SR Ca2+-ATPase activity and phosphorylation level of phospholamban. Am J Physiol. 1999;277:H474–H480

PII: S1547-5271(10)00450-9

doi: 10.1016/j.hrthm.2010.05.001

Heart Rhythm
Volume 7, Issue 8 , Pages 1102-1103 , August 2010

Article Tools