Heart Rhythm
Volume 7, Issue 12 , Pages 1862-1869 , December 2010

Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability

  • Andreas Blana, MD

      Affiliations

    • Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany
    • ,
  • Sven Kaese, BS

      Affiliations

    • Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany
    • ,
  • Lisa Fortmüller, VetD

      Affiliations

    • Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany
    • Interdisciplinary Center for Clinical Research Münster (IZKF Münster), Münster, Germany
    • ,
  • Sandra Laakmann, VetD

      Affiliations

    • Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany
    • Interdisciplinary Center for Clinical Research Münster (IZKF Münster), Münster, Germany
    • ,
  • Dierk Damke, MD

      Affiliations

    • Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany
    • ,
  • Kelly van Bragt, BS

      Affiliations

    • Department of Physiology, University Maastricht, Maastricht, The Netherlands
    • ,
  • Jens Eckstein, MD

      Affiliations

    • Department of Physiology, University Maastricht, Maastricht, The Netherlands
    • ,
  • Ilaria Piccini, PhD

      Affiliations

    • Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany
    • ,
  • Uwe Kirchhefer, MD

      Affiliations

    • Interdisciplinary Center for Clinical Research Münster (IZKF Münster), Münster, Germany
    • Institute of Pharmacology and Toxicology, University Hospital Münster, Münster, Germany
    • ,
  • Stanley Nattel, MD, FHRS

      Affiliations

    • Montreal Heart Institute and Université de Montréal, Montreal, Canada
    • ,
  • Günter Breithardt, MD, FHRS

      Affiliations

    • Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany
    • ,
  • Peter Carmeliet, MD

      Affiliations

    • Vesalius Research Center–VIB, Vesalius Research Center–KU Leuven, Leuven, Belgium
    • ,
  • Edward Carmeliet, PhD

      Affiliations

    • Vesalius Research Center–VIB, Vesalius Research Center–KU Leuven, Leuven, Belgium
    • ,
  • Ulrich Schotten, MD, PhD

      Affiliations

    • Department of Physiology, University Maastricht, Maastricht, The Netherlands
    • ,
  • Sander Verheule, PhD

      Affiliations

    • Department of Physiology, University Maastricht, Maastricht, The Netherlands
    • ,
  • Paulus Kirchhof, MD, FHRS

      Affiliations

    • Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany
    • Interdisciplinary Center for Clinical Research Münster (IZKF Münster), Münster, Germany
    • ,
  • Larissa Fabritz, MD

      Affiliations

    • Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany
    • Interdisciplinary Center for Clinical Research Münster (IZKF Münster), Münster, Germany
    • Corresponding Author InformationAddress reprint requests and correspondence: Dr. Larissa Fabritz, Department of Cardiology and Angiology, University Hospital Münster, D-48129 Münster, Germany

Received 9 October 2009 ,Accepted 17 August 2010.

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 Financial support from Medical Faculty, University of Münster, “Innovative Medical Research,” IMF FA120431 (LF), and KA620805 (SvK); Deutsche Forschungsgemeinschaft DFG FA 413-3/1 (LF), Ki-731/1-1 (PK), SFB 656 MoBil, C3 (LF), A8 (LF, PK), Z2; IZKF Münster Kih1/020/07 (LF, UK); Core Unit CarTel (PK), Canadian Institutes of Health Research (SN); and Fondation Leducq ENAFRA (PK, SN, US).

PII: S1547-5271(10)00826-X

doi: 10.1016/j.hrthm.2010.08.016

Heart Rhythm
Volume 7, Issue 12 , Pages 1862-1869 , December 2010

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