| Clinical |
| Atrial Fibrillation |
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Statin Use And Postoperative Atrial Fibrillation After Major Noncardiac Surgery
09 September 2011
Background: Although statin lipid-lowering medications likely reduce perioperative ischemic complications, few data exist to describe statins' effects on risk for and outcomes of atrial fibrillation f...
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Prashant D. Bhave,
L. Elizabeth Goldman,
Eric Vittinghoff,
Judith H. Maselli,
Andrew Auerbach
et al.
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163-169
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| Editorial Commentary |
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Expanding the role of statins in postoperative atrial fibrillation
28 September 2011
Atrial fibrillation (AF) is a growing public health problem, predicted to impact as many as 15 million people by 2050. In addition to its well-known associated risks in an outpatient population, isola...
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George Thomas,
Bruce B. Lerman
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170-171
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Atorvastatin for prevention of atrial fibrillation recurrence following pulmonary vein isolation: A double-blind, placebo-controlled, randomized trial
14 September 2011
Background: It is known that statins are effective in preventing atrial fibrillation (AF) in patients undergoing cardiac surgery. Objective: The purpose of this study was to evaluate the efficacy of s...
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Mahmoud Suleiman,
Celeste Koestler,
Amir Lerman,
Francisco Lopez-Jimenez,
Regina Herges,
David Hodge,
David Bradley,
Yong-Mei Cha,
Peter A. Brady,
Thomas M. Munger,
Samuel J. Asirvatham,
Douglas L. Packer,
Paul A. Friedman
et al.
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172-178
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| Editorial Commentary |
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Neutral effects of statins to prevent atrial fibrillation recurrences after catheter ablation of atrial fibrillation: Should we bury upstream therapy for secondary prevention of atrial fibrillation?
14 October 2011
Statins have been introduced to inhibit the main enzyme of cholesterol synthesis 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA-reductase) to lower low-density lipoprotein cholesterol levels. In a...
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Andreas Goette
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179-180
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Is there a relationship between complex fractionated atrial electrograms recorded during atrial fibrillation and sinus rhythm fractionation?
26 September 2011
Background: Ablation of persistent atrial fibrillation (AF) may require adjunctive methods of substrate modification. Both ablation-targeting complex fractionated atrial electrograms (CFAEs) recorded ...
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Laszlo Saghy,
David J. Callans,
Fermin Garcia,
David Lin,
Francis E. Marchlinski,
Michael Riley,
Sanjay Dixit,
Wendy S. Tzou,
Harris M. Haqqani,
Robert Pap,
Steven Kim,
Edward P. Gerstenfeld
et al.
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181-188
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| Ablation |
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Cellular damage, platelet activation, and inflammatory response after pulmonary vein isolation: A randomized study comparing radiofrequency ablation with cryoablation
14 September 2011
Background: Experimental data suggest that use of cryoablation in pulmonary vein isolation (PVI) is associated with less cell damage and less thrombus formation compared to radiofrequency (RF) energy....
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Claudia Herrera Siklódy,
Thomas Arentz,
Jan Minners,
Laurence Jesel,
Christian Stratz,
Christian M. Valina,
Reinhold Weber,
Dietrich Kalusche,
Florence Toti,
Olivier Morel,
Dietmar Trenk
et al.
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189-196
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| Editorial Commentary |
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Thromboembolic risk of the hot- and cold-catheter ablation for atrial fibrillation
05 October 2011
In the last decade, catheter ablation procedures aimed at the electrical isolation of arrhythmogenic pulmonary veins (PVs) and/or modification of left atrial substrate have evolved as an important the...
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Chung-Wah Siu,
Hung-Fat Tse
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197-198
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| Devices |
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Cardiac rhythm devices in the pediatric population: Utilization and complications
09 September 2011
Background: Cardiac rhythm devices are important in the management of pediatric patients with rhythm abnormalities, although factors driving utilization are poorly understood. Objective: This study so...
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Richard J. Czosek,
Karthikeyan Meganathan,
Jeffrey B. Anderson,
Timothy K. Knilans,
Bradley S. Marino,
Pamela C. Heaton
et al.
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199-208
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| Editorial Commentary |
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Orbits and implants: Trends in indications, utilization, and complications in pediatric device therapy
26 September 2011
“I don't pretend we have all the answers. But the questions are certainly worth thinking about.”—Sir Arthur Charles Clarke, 1917–2008
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Joel A. Kirsh
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209-210
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Feasibility of postmortem device acquisition for potential reuse in underserved nations
26 September 2011
Objectives: The purpose of the present study was to examine the feasibility and efficacy of a program to acquire devices with adequate battery life from crematories and funeral homes for potential reu...
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Timir S. Baman,
Thomas Crawford,
Patricia Sovitch,
Pascal Meier,
Nathan Sovitch,
Lindsey Gakenheimer,
James Kirkpatrick,
Brad Wasserman,
George Samson,
Hakan Oral,
Kim A. Eagle
et al.
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211-214
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| Editorial Commentary |
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You shouldn’t take it with you: Postmortem device reuse
26 December 2011
Antiarrhythmia devices—pacemakers and implantable cardioverter-defibrillators (ICDs)—are expensive scarce world resources that are available to the majority of the population in the economic “haves” c...
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William J. Groh
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215-216
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Celivarone in patients with an implantable cardioverter-defibrillator: Adjunctive therapy for the reduction of ventricular arrhythmia-triggered implantable cardioverter-defibrillator interventions
05 October 2011
Background: Implantable cardioverter-defibrillators (ICDs) remain the treatment of choice for the prevention of life-threatening arrhythmias. However, many patients with ICDs require additional antiar...
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Olivera Gojkovic,
Etienne M. Aliot,
Alessandro Capucci,
Stuart J. Connolly,
Harry Crijns,
Stefan H. Hohnloser,
Piotr Kulakowski,
Denis Roy,
David Radzik,
Bramah N. Singh,
Peter R. Kowey
et al.
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217-224.e2
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| Genetic |
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Distinguishing “benign” from “malignant early repolarization”: The value of the ST-segment morphology
12 September 2011
Background: Means for distinguishing the very common “benign early repolarization” from the very rare but malignant form are needed. Recently, the presence of early repolarization with “horizontal ST ...
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Raphael Rosso,
Eran Glikson,
Bernard Belhassen,
Amos Katz,
Amir Halkin,
Arie Steinvil,
Sami Viskin
et al.
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225-229
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| Editorial Commentary |
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Early repolarization patterns: The good, the bad, and the ugly?
26 September 2011
The innocence of the electrocardiographic (ECG) pattern of early repolarization (ER) has been challenged by the recent association of the ER pattern in inferolateral leads with idiopathic ventricular ...
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Mark G. Hoogendijk,
Mark Potse,
Ruben Coronel
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230-231
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Ajmaline attenuates electrocardiogram characteristics of inferolateral early repolarization
12 September 2011
Background: J waves are the hallmark of both inferolateral early repolarization (ER) and Brugada syndrome. While ajmaline, a class 1a antiarrhythmic drug, accentuates the J wave in Brugada syndrome, i...
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Laurent Roten,
Nicolas Derval,
Frédéric Sacher,
Patrizio Pascale,
Stephen B. Wilton,
Daniel Scherr,
Ashok Shah,
Michala E.F. Pedersen,
Amir S. Jadidi,
Shinsuke Miyazaki,
Sébastien Knecht,
Mélèze Hocini,
Pierre Jaïs,
Michel Haïssaguerre
et al.
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232-239
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| Editorial Commentary |
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Drug challenge with sodium-channel blockade: Improving phenotypic characterization of early repolarization
03 October 2011
“Early repolarization” (ER), first described by Shipley and Halloran in 1936 as ST-segment elevation in the absence of coronary artery disease, generally has been considered a benign electrocardiograp...
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Leonard Ilkhanoff,
Bradley P. Knight
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240-241
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Clinical impact of the number of extrastimuli in programmed electrical stimulation in patients with Brugada type 1 electrocardiogram
21 September 2011
Background: Use of programmed electrical stimulation (PES) for risk stratification of Brugada syndrome (BrS) is controversial. Objective: To elucidate the role of the number of extrastimuli during PES...
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Hisaki Makimoto,
Shiro Kamakura,
Naohiko Aihara,
Takashi Noda,
Ikutaro Nakajima,
Teruki Yokoyama,
Atsushi Doi,
Hiro Kawata,
Yuko Yamada,
Hideo Okamura,
Kazuhiro Satomi,
Takeshi Aiba,
Wataru Shimizu
et al.
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242-248
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Vagal activity modulates spontaneous augmentation of J-wave elevation in patients with idiopathic ventricular fibrillation
21 September 2011
Background: Although J-wave elevation in the inferolateral leads could be related to idiopathic ventricular fibrillation (IVF), little is known about the pathophysiologic characteristics of J-wave ele...
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Koichi Mizumaki,
Kunihiro Nishida,
Jotaro Iwamoto,
Yosuke Nakatani,
Yoshiaki Yamaguchi,
Tamotsu Sakamoto,
Takayuki Tsuneda,
Naoya Kataoka,
Hiroshi Inoue
et al.
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249-255
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| Editorial Commentary |
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The slowest, the worst: Demonstrating the evidence
05 October 2011
In the current issue of HeartRhythm, Mizumaki and colleagues demonstrate that J-wave amplitude was independently modulated by both heart rate and vagal activity in normal subjects and in patients with...
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Philippe Maury,
Frederic Sacher
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256-257
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| Imaging/Mapping |
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High-density epicardial mapping of the pulmonary vein–left atrial junction in humans: Insights into mechanisms of pulmonary vein arrhythmogenesis
09 September 2011
Background: The pulmonary veins (PVs) and the PV–LA (left atrium) junction are established sources of triggers initiating atrial fibrillation. In addition, they have been implicated in the maintenance...
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Geoffrey Lee,
Steven Spence,
Andrew Teh,
John Goldblatt,
Marco Larobina,
Victoria Atkinson,
Robin Brown,
Joseph B. Morton,
Prashanthan Sanders,
Peter M. Kistler,
Jonathan M. Kalman
et al.
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258-264
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| Experimental Genetic |
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Genetic suppression of atrial fibrillation using a dominant-negative ether-a-go-go–related gene mutant
09 September 2011
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Gene therapy–dependent modulation of atrial electrophysiology may provide a more specific alternative to pharmacol...
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Radim Soucek,
Dierk Thomas,
Kamilla Kelemen,
Olympia Bikou,
Claudia Seyler,
Frederik Voss,
Rüdiger Becker,
Michael Koenen,
Hugo A. Katus,
Alexander Bauer
et al.
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265-272
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| Editorial Commentary |
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Genetic treatment of heart rhythm disorders—where do we stand?
19 September 2011
Groundbreaking discoveries on genetic loci that underlie arrhythmia syndromes, which commenced in the early 1990s, have immensely increased our understanding of these syndromes. These discoveries also...
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Pieter G. Postema,
Hanno L. Tan
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273-274
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Arrhythmia formation in subclinical (“silent”) long QT syndrome requires multiple insults: Quantitative mechanistic study using the KCNQ1 mutation Q357R as example
26 September 2011
Background: In subclinical or silent long QT syndrome, the QT interval is normal under basal conditions. The hypothesis that insults to the repolarization reserve may cause arrhythmias in silent mutat...
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Thomas O'Hara,
Yoram Rudy
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275-282
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| Editorial Commentary |
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Silent mutation in long QT syndrome: Pathogenicity prediction by computer simulation
13 October 2011
Congenital long QT syndrome (LQTS) is an inherited cardiac disorder characterized by prolongation of the QT interval on the surface electrocardiogram. Patients with LQTS are predisposed to ventricular...
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Zahurul A. Bhuiyan
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283-284
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| Case Report |
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Congenital type 1 long QT syndrome unmasked by a highly caffeinated energy drink
13 October 2011
Long QT syndrome (LQTS) is an uncommon genetic disease that affects approximately 1 in 2500 people and can present with syncope, cardiogenic seizures, and/or sudden cardiac death. This cardiac channel...
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Keith A. Dufendach,
Justin M. Horner,
Bryan C. Cannon,
Michael J. Ackerman
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285-288
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| Contemporary Review--Associate Editor: Sami Viskin |
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Efficacy and safety of atrial fibrillation ablation with phased radiofrequency energy and multielectrode catheters
09 September 2011
Focal radiofrequency (RF) ablation guided by 3-dimesnional (3D) mapping systems has shown considerable success in treating paroxysmal and persistent atrial fibrillation (AF). Unfortunately, the proced...
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Jason G. Andrade,
Marc Dubuc,
Lena Rivard,
Peter G. Guerra,
Blandine Mondesert,
Laurent Macle,
Bernard Thibault,
Mario Talajic,
Denis Roy,
Paul Khairy
et al.
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289-296
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| Editorial Commentary |
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Introduction of new atrial fibrillation ablation technology into clinical practice: The cart before the horse?
28 September 2011
Over the past decade, point-by-point ablation using irrigated radiofrequency (RF) ablation has become the apparent gold standard for pulmonary vein (PV) isolation. An enormous body of observational an...
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Jonathan M. Kalman,
Prashanthan Sanders
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297-298
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| Point/Counterpoint |
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The funny current has a major pacemaking role in the sinus node
19 September 2011
The ability to produce rhythmic, spontaneous contractions is a primary function of the heart, and it has intrigued generations of cardiac physiologists in the search for the underlying processes. Spon...
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Dario DiFrancesco,
Denis Noble
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299-301
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The funny current in the context of the coupled-clock pacemaker cell system
19 September 2011
It has been now widely documented in many laboratories in many species (review) that local Ca2+ releases (LCRs), generated by the sarcoplasmic reticulum (SR) via spontaneous ryanodine receptor (RyR) a...
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Victor A. Maltsev,
Edward G. Lakatta
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302-307
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| Viewpoint--Associate Editor: Yoram Rudy |
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The role of gap junctions in the arrhythmias of ischemia and infarction
21 September 2011
Gap junction remodeling (changes in function, quantity, and location) likely contributes to arrhythmias in ischemia and infarction by altering conduction, refractoriness, and automaticity, therefore o...
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Andrew L. Wit,
Nicholas S. Peters
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308-311
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| Featured Arrhythmia--Associate Editor: Fred Morady |
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Entrainment versus resetting of a long RP tachycardia: What is the diagnosis?
25 November 2010
A 71-year-old man with a history of chronic obstructive pulmonary disease presented for electrophysiological study because of recurrent hospitalizations due to a long-RP-interval narrow complex tachyc...
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Reginald T. Ho,
David L. Fischman
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312-314
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| Image--Associate Editor: David S. Rosenbaum |
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Retrograde placement of a defibrillator lead through the pulmonary valve
10 November 2010
We report the placement of an implantable cardioverter-defibrillator (ICD) lead using a retrograde access to the right ventricle via the pulmonary artery and the pulmonary valve in a patient with prev...
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Tobias Reichlin,
Christian Sticherling,
Jean-Luc Crevoisier,
Stefan Osswald
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315-316
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| EP News--Associate Editors: Peng-Sheng Chen and N.A. Mark Estes III |
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EP News: Basic and Translational
26 December 2011
During the American Heart Association Annual Meeting, Rizzo et al (Circulation 2011:124:A13059) reported pathological characteristics of stellate ganglia resected from 5 long QT syndrome (LQTS) and 5 ...
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Peng-Sheng Chen
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317
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EP News Clinical
26 December 2011
Imazio and colleagues (Circulation 2011 Nov 22; 124(21):2290–2295. Epub 2011 Nov 16 PMID: 22090167) evaluated colchicine (C) for the prevention of post-operative AF (POAF) after cardiac surgery in 336...
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N.A. Mark Estes
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318
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| Letters to the Editor |
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To the Editor–Ablation of persistent atrial fibrillation
14 November 2011
Rostock et al confirm the difficulty faced in the ablation of persistent atrial fibrillation (AF) in their study examining the long-term success of catheter ablation in this group of patients, with a ...
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Ratika Parkash,
Anthony S.L. Tang
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e1
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Reply to the Editor—Persistent Atrial Fibrillation
14 November 2011
We thank Drs. Parkash and Tang for their interest in our recent work. The authors outlined that additional substrate ablation beyond the pulmonary veins is required in patients with persistent atrial ...
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Thomas Rostock,
Stephan Willems
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e1-e2
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Letter to the Editor—Atrial fibrillation: An inflammatory and autoimmune disorder
21 November 2011
Atrial fibrillation (AF) is an established inflammatory disorder. Autoimmunity has been suggested to play an important role as autoantibodies have been identified in AF. Identification of contactin-2 ...
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David O. Schairer,
William R. Levis
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e2
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Reply to the Editor—Atrial Fibrillation: An Inflammatory and Autoimmune Disorder
18 November 2011
Many factors contribute to the pathogenesis of atrial fibrillation, including electrical, structural, neurohumoral, and inflammatory mechanisms. Our review indicated that various autoantibodies that m...
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Hon-Chi Lee,
Xiao-Li Wang,
Kristin T. Huang,
Win-Kuang Shen,
Mark R. Pittelkow
et al.
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e2-e3
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