The Heart Rhythm Society convened a research symposium on December 9–10, 2013, in
Washington, DC, that focused on the prevention of atrial fibrillation (AF) as well
as AF-related stroke and morbidity. Attendees sought to summarize advances in understanding
AF since a 2008 National Institutes of Health (NIH) conference on this topic
1
and to identify continued knowledge gaps and current research priorities. The research
symposium also sought to identify key deficiencies and opportunities in research infrastructure,
operations, and methodologies. The committee sought to identify both basic research
targets and how clinical AF research could be improved in the current health care
environment. This whitepaper summarizes our deliberations in an effort to accelerate
progress toward preventing AF and its consequences. Although largely focused on primary
prevention of AF, the paper also addresses some aspects of secondary prevention of
recurrent AF due to the continuum of risk factors that contribute to arrhythmogenesis,
permissive left atrial (LA) substrates, and the emergence of AF.Abbreviations:
ACEi (angiotensin-converting enzyme inhibitor), AF (atrial fibrillation), A-II (angiotensin-II), ANP (atrial natriuretic peptide), ARB (angiotensin receptor blocker), BP (blood pressure), BMI (body mass index), BNP (brain natriuretic peptide), CaMKII (calmodulin-dependent kinase II), DAD (delayed afterdepolarization), EAD (early afterdepolarization), ECM (electrocardiographic mapping), EHR (electronic health record), ET-1 (endothelin-1), GGA (geranyl-geranylacetone), GP (ganglionated plexi), HDAC6 (histone deacetylase-6), HF (heart failure), HSP (heat shock protein), LA (left atrium), LAA (left atrial appendage), LGE-CMR (late gadolinium enhanced cardiac magnetic resonance imaging), LV (left ventricle), MRI (magnetic resonance imaging), NIH (National Institutes of Health), NOAC (non–vitamin K-dependent oral anticoagulant), NP (natriuretic peptide), OAC (oral anticoagulant), PAC (premature atrial contraction), pAF (paroxysmal atrial fibrillation), PV (pulmonary vein), PVI (pulmonary vein isolation), RAAS (renin–angiotensin–aldosterone system), RCT (randomized controlled trial), RSD (renal sympathetic denervation), SDB (sleep disordered breathing), SR (sarcoplasmic reticulum), TGF (transforming growth factor), TTR (time in therapeutic range)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 17, 2014
Footnotes
Developed in collaboration with and endorsed by the European Heart Rhythm Association (EHRA) and the Canadian Heart Rhythm Society (CHRS).
Identification
Copyright
© 2015 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
