Statins' broad spectrum of beneficial cardiovascular effects, including reduction
in coronary artery disease deaths and myocardial infarctions (MIs), often evokes the
term pleiotropy. This therapeutic accolade appears well deserved, given the multimodal
actions by which this class of lipid-lowering agents exerts its salutary influences
on coronary, cerebral, and other vasculatures. The overall reduction in ischemic burden
owing to amelioration of plaque progression results from diverse effects on endothelial
function, signaling pathways of inflammation, endothelial nitric oxide synthesis,
platelet activation, angiotensin II receptor regulation, and plaque stabilization,
to name a few.
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Article info
Publication history
Published online: June 09, 2017
Footnotes
Dr Verrier is co-inventor of the Modified Moving Average method for T-wave alternans analysis, which is assigned to Beth Israel Deaconess Medical Center and licensed by GE Healthcare.
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