The pathophysiological mechanisms underlying the J-wave syndromes (JWSs), including
Brugada syndrome (BrS) and early repolarization syndrome (ERS), remain a matter of
debate. At the heart of the controversy is the question of whether the electrocardiographic
(ECG) phenotypes and arrhythmogenic substrates are due principally to abnormal depolarization, repolarization, or both.
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Article info
Publication history
Published online: November 19, 2018
Footnotes
Supported by NHLBI (HL47678 and HL138103) and the Martha and Wistar Morris Fund. The authors have reported that they have no conflicts relevant to the contents of this paper to disclose.
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© 2018 Heart Rhythm Society. All rights reserved.
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- Depolarization versus repolarization abnormality underlying inferolateral J-wave syndromes: New concepts in sudden cardiac death with apparently normal heartsHeart RhythmVol. 16Issue 5
- PreviewEarly repolarization indicates a distinct electrocardiographic phenotype affecting the junction between the QRS complex and the ST segment in inferolateral leads (inferolateral J-wave syndromes). It has been considered a benign electrocardiographic variant for decades, but recent clinical studies have demonstrated its arrhythmogenicity in a small subset, supported by experimental studies showing transmural dispersion of repolarization. Here we review the current knowledge and the issues of risk stratification that limit clinical management.
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