Reply to the Editor— The site of origin of the ventricular premature beat in a patient with 2 different P-wave morphologies

Published:December 28, 2018DOI:
      I welcome the letter of Drs Alizadeh and Keikhavani concerning the ventricular premature beat (VPB) in our recent article
      • Wellens H.J.
      Two different P waves after a single ventricular premature beat in a 33-year-old man.
      because it gives attention to our ability to locate ectopic ventricular rhythms by giving a close look at their QRS configuration. This is an increasingly important topic in relation to treatment by catheter ablation. While discussing the site of origin of the VPB in relation to QRS configuration, they refer to publications by the clinical electrophysiology group from Birmingham, AL, that contributed extensively to that issue. Two publications are mentioned (references 2 and 3 in their letter) about QRS characteristics favoring a left interventricular septal origin adjacent to the His bundle. I prefer a right ventricular origin on the basis of the following findings: the left bundle branch block QRS configuration; the frontal QRS axis of 0° with a negative QS complex in lead III, and a markedly positive R wave in lead aVL. This is an unlikely axis for impulse formation close to the His bundle, where an intermediate frontal QRS axis is expected. Also, the QS configuration, without initial positivity in lead V1, does not support a left septal origin. Both the frontal plane QRS axis and the transition from a QS complex in lead V1 to an R wave in lead V2 during the VPB reminds one of the delta wave characteristics in a right posteroseptal accessory pathway—findings, in my opinion, supporting a posterior right ventricular origin close to the interventricular septum.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Heart Rhythm
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Wellens H.J.
        Two different P waves after a single ventricular premature beat in a 33-year-old man.
        Heart Rhythm. 2018; 15: 1891-1892

      Linked Article