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Cardiac sarcoidosis mimicking definite arrhythmogenic right ventricular cardiomyopathy

  • Richard N.W. Hauer
    Correspondence
    Address reprint requests and correspondence: Dr Richard N.W. Hauer, Department of Cardiology, University Medical Center Utrecht, Netherlands Heart Institute, Utrecht, Boslaan 8, 1405 CB, Bussum, The Netherlands.
    Affiliations
    Department of Cardiology, University Medical Center Utrecht, Netherlands Heart Institute, Utrecht, The Netherlands
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Published:October 19, 2020DOI:https://doi.org/10.1016/j.hrthm.2020.10.012
      The criterion standard for arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis is the histopathological detection of specified myocardial fibrofatty and fibrotic alterations. This is relatively straightforward from autopsy or cardiac explant specimen. Detection from biopsy material, however, is hampered by the segmental nature of ARVC and the invasiveness of the procedure with associated risk. Because of these limitations, a surrogate standard such as Task Force Criteria (TFC) has been developed by international consensus and was reported in both Circulation and European Heart Journal in 2010 (2010 TFC).
      • Marcus F.I.
      • McKenna W.J.
      • Sherrill D.
      • et al.
      Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria.
      The 2010 TFC consists of 6 sets of clinically available major and minor criteria and is used worldwide to facilitate ARVC diagnosis. In addition, these 2010 TFC facilitated research by more easy comparison of scientific and clinical studies. Definite ARVC diagnosis is fulfilled by at least 2 major, or 1 major and 2 minor, or 4 minor criteria from the 6 sets. However, this fulfillment may be obtained by other disease entities as well, and thus these other diseases should be excluded for proper ARVC diagnosis.
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      References

        • Marcus F.I.
        • McKenna W.J.
        • Sherrill D.
        • et al.
        Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria.
        Circulation. 2010; 121: 1533-1541
        • Ladyjanskaia G.A.
        • Basso C.
        • Hobbelink M.G.G.
        • et al.
        Sarcoid myocarditis with ventricular tachycardia mimicking ARVD/C.
        J Cardiovasc Electrophysiol. 2010; 21: 94-98
        • Vasaiwala S.C.
        • Finn C.
        • Delpriore J.
        • et al.
        Prospective study of cardiac sarcoid mimicking arrhythmogenic right ventricular dysplasia.
        J Cardiovasc Electrophysiol. 2009; 20: 473-476
        • Philips B.
        • Madhavan S.
        • James C.A.
        • et al.
        Arrhythmogenic right ventricular dysplasia/cardiomyopathy and cardiac sarcoidosis: distinguishing features when the diagnosis is unclear.
        Circ Arrhythm Electrophysiol. 2014; 7: 230-236
        • Soejima K.
        • Yada H.
        The work-up and management of patients with apparent or subclinical cardiac sarcoidosis: with emphasis on the associated heart rhythm abnormalities.
        J Cardiovasc Electrophysiol. 2009; 20: 578-583
        • Gasperetti A.
        • Rossi V.A.
        • Chiodini A.
        • et al.
        Differentiating hereditary arrhythmogenic right ventricular cardiomyopathy from cardiac sarcoidosis fulfilling 2010 ARVC Task Force Criteria.
        Heart Rhythm. 2021; 18: 231-238
        • Te Riele A.S.
        • James C.A.
        • Philips B.
        • et al.
        Mutation-positive arrhythmogenic right ventricular dysplasia/ cardiomyopathy: the triangle of dysplasia displaced.
        J Cardiovasc Electrophysiol. 2013; 24: 1311-1320
        • Basso C.
        • Thiene G.
        • Corrado D.
        • et al.
        Arrhythmogenic right ventricular cardiomyopathy: dysplasia, dystrophy, or myocarditis?.
        Circulation. 1996; 94: 983-991
        • Protonotarios A.
        • Wicks E.
        • Ashworth M.
        • et al.
        Prevalence of 18F-fluorodeoxyglucose positron emission tomography abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy.
        Int J Cardiol. 2019; 284: 99-104
        • Roudijk R.W.
        • Bosman L.P.
        • Van der Heijden J.F.
        • et al.
        Quantitative approach to fragmented QRS in arrhythmogenic cardiomyopathy: from disease towards asymptomatic carriers of pathogenic variants.
        J Clin Med. 2020; 9: 545
        • Hoogendoorn J.C.
        • Sramko M.
        • Venlet J.
        • et al.
        Electroanatomical voltage mapping to distinguish right-sided cardiac sarcoidosis from arrhythmogenic right ventricular cardiomyopathy.
        JACC Clin Electrophysiol. 2020; 6: 696-707

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