Advertisement

Heartbeat music

  • Edward G. Lakatta
    Correspondence
    Address reprint requests and correspondence: Dr Edward G. Lakatta, Laboratory of Cardiovascular Science Intramural Research Program, National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224.
    Affiliations
    Laboratory of Cardiovascular Science Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland
    Search for articles by this author
Published:January 16, 2021DOI:https://doi.org/10.1016/j.hrthm.2021.01.011
      The heart is a central player within a hierarchical system of clocks operating within an autonomic neurovisceral axis that creates and synchronizes rhythmic functions ranging from milliseconds to days and beyond.
      • Shivkumar K.
      • Ajijola O.A.
      • Anand I.
      • et al.
      Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic and Personal
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Heart Rhythm
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Shivkumar K.
        • Ajijola O.A.
        • Anand I.
        • et al.
        Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics.
        J Physiol. 2016; 594: 3911-3954
        • Armour J.A.
        Potential clinical relevance of the ‘little brain’ on the mammalian heart.
        Exp Physiol. 2008; 93: 165-176
        • Lakatta E.G.
        • Malsev V.A.
        • Vinogradova T.M.
        A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks control the timekeeping mechanism of the heart’s pacemaker.
        Circ Res. 2010; 106: 659-673
        • Lakatta E.G.
        • Yaniv Y.
        • Maltsev V.A.
        Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks: focus on “The cardiomyocyte molecular clock, regulation of Scn5A, arrhythmia susceptibility.
        Am J Physiol Cell Physiol. 2013; 304: C941-C944
        • D’Souza A.
        • Wang Y.
        • Anderson C.
        • et al.
        A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate.
        Heart Rhythm. 2021; 18: 801-810
        • Lyashkov A.E.
        • Behar J.
        • Lakatta E.G.
        • Yaniv Y.
        • Maltsev V.A.
        Positive feedback mechanisms among local Ca releases, NCX, and ICaL ignite pacemaker action potentials.
        Biophys J. 2018; 114: 1176-1189
        • Tsutsui K.
        • Monfredi O.L.
        • Sirenko-Tagirova S.G.
        • et al.
        A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells.
        Sci Signal. 2018; 11eaap7608
      1. Sirenko ST, Tsutsui K, Tarasov K, et al. Self-similar synchronization of calcium and membrane potential transitions during AP cycles predict HR across species [published online ahead of print December 22, 2020]. bioRxiv. https://doi.org/10.1101/2020.10.26.355412.

      2. Yang D, Lyashkov AE, Morrell CH, et al. Self-similar action potential cycle-to-cycle variability of Ca2+ and current oscillators in cardiac pacemaker cells [published online ahead of print September 2, 2020]. bioRxiv. https://doi.org/10.1101/2020.09.01.277756.

        • Weiss J.M.
        • Zhilin Qu
        The sinus node: still mysterious after all these years.
        JACC Clin Electrophysiol. 2020; 6: 1841-1843
        • Lakatta E.G.
        • Maltsev V.A.
        Reprogramming paces the heart.
        Nat Biotechnol. 2013; 31: 31-32
        • Bychkov R.
        • Juhaszova M.
        • Tsutsui K.
        • et al.
        Synchronized cardiac impulses emerge from heterogeneous local calcium signals within and among cells of pacemaker tissue.
        JACC Clin Electrophysiol. 2020; 6: 907-931
        • DiFrancesco D.
        • Tortora P.
        Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.
        Nature. 1991; 351: 145-147
        • Fenske S.
        • Hennis K.
        • Rötzer R.D.
        • et al.
        cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells.
        Nat Commun. 2020; 11: 5555
        • Vinogradova T.M.
        • Lakatta E.G.
        Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.
        J Mol Cell Cardiol. 2009; 47: 456-474
        • Maltsev V.A.
        • Lakatta E.G.
        Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.
        Am J Physiol. 2009; 296: H594-H615

      Linked Article