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Mechanoelectric feedback in the human heart: A causal affair

  • Ursula Ravens
    Correspondence
    Address reprint requests and correspondence: Dr Ursula Ravens, Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, Medical Center and Faculty of Medicine, University of Freiburg, Elsässer Strasse 2Q, 79110 Freibrug, Germany.
    Affiliations
    Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany
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  • Peter Kohl
    Affiliations
    Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany
    Search for articles by this author
      Cardiac mechanoelectric feedback—the process by which the mechanical environment alters the electrical behavior of the heart—is coming of age. As shown in this issue of Heart Rhythm Journal by Orini et al,
      • Orini M.
      • Taggart P.
      • Bhuva A.
      • et al.
      Direct in vivo assessment of global and regional mechanoelectric feedback in the intact human heart.
      it is present and functionally relevant in the intact human heart.
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      References

        • Orini M.
        • Taggart P.
        • Bhuva A.
        • et al.
        Direct in vivo assessment of global and regional mechanoelectric feedback in the intact human heart.
        Heart Rhythm. 2021; 18: 1406-1413
        • Ashikaga H.
        • Coppola B.A.
        • Hopenfeld B.
        • et al.
        Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo.
        J Am Coll Cardiol. 2007; 49: 909-916
        • Katz A.M.
        • Katz P.B.
        Homogeneity out of heterogeneity.
        Circulation. 1989; 79: 712-717
        • Markhasin V.S.
        • Solovyova O.
        • Katsnelson L.B.
        • et al.
        Mechano-electric interactions in heterogeneous myocardium: development of fundamental experimental and theoretical models.
        Prog Biophys Mol Biol. 2003; 82: 207-220
        • Nagueh S.F.
        Mechanical dyssynchrony in congestive heart failure: diagnostic and therapeutic implications.
        J Am Coll Cardiol. 2008; 51: 18-22
        • Lab M.J.
        Mechanoelectric feedback (transduction) in heart: concepts and implications.
        Cardiovasc Res. 1996; 32: 3-14
        • Zabel M.
        • Koller B.S.
        • Sachs F.
        • et al.
        Stretch-induced voltage changes in the isolated beating heart: importance of the timing of stretch and implications for stretch-activated ion channels.
        Cardiovasc Res. 1996; 32: 120-130
        • Mills R.W.
        • Narayan S.M.
        • McCulloch A.D.
        Mechanisms of conduction slowing during myocardial stretch by ventricular volume loading in the rabbit.
        Am J Physiol. 2008; 295: H1270-H1278
        • Quinn T.A.
        • Kohl P.
        Cardiac mechano-electric coupling: acute effects of mechanical stimulation on heart rate and rhythm.
        Physiol Rev. 2021; 101: 37-92
        • Gallacher D.J.
        • Van de Water A.
        • van der Linde H.
        • et al.
        In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome.
        Cardiovasc Res. 2007; 76: 247-256
        • Odening K.E.
        • Jung B.A.
        • Lang C.N.
        • et al.
        Spatial correlation of action potential duration and diastolic dysfunction in transgenic and drug-induced LQT2 rabbits.
        Heart Rhythm. 2013; 10: 1533-1541
        • Bernardi L.
        • Keller F.
        • Sanders M.
        • et al.
        Respiratory sinus arrhythmia in the denervated human heart.
        J Appl Physiol. 1989; 67: 1447-1455
        • Epstein A.E.
        • DiMarco J.P.
        • Ellenbogen K.A.
        • et al.
        2012 ACCF/AHA/HRS focused update incorporated into the ACCF/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the ACCF/AHA Task Force on Practice Guidelines and the HRS.
        J Am Coll Cardiol. 2013; 61: e6-e75
        • Edvardsen T.
        • Urheim S.
        • Skulstad H.
        • et al.
        Quantification of left ventricular systolic function by tissue Doppler echocardiography: added value of measuring pre- and postejection velocities in ischemic myocardium.
        Circulation. 2002; 105: 2071-2077
        • Levine J.H.
        • Guarnieri T.
        • Kadish A.H.
        • et al.
        Changes in myocardial repolarization in patients undergoing balloon valvuloplasty for congenital pulmonary stenosis: evidence for contraction-excitation feedback in humans.
        Circulation. 1988; 77: 70-77
        • Taggart P.
        • Sutton P.
        • Lab M.
        • et al.
        Effect of abrupt changes in ventricular loading on repolarization induced by transient aortic occlusion in humans.
        Am J Physiol. 1992; 263: H816-H823

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