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B-AB13-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL

      The QT interval, a marker of ventricular repolarization, is a heritable, independent predictor of risk for ventricular arrhythmias and sudden cardiac death (SCD). Previous genome-wide association studies (GWAS) of the QT interval have highlighted pathways regulating cardiac ion channels, calcium signaling and myocyte internal structure. However, a large proportion of the heritability remains unexplained, suggesting additional mechanisms remain undiscovered.
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