The QT interval, a marker of ventricular repolarization, is a heritable, independent
predictor of risk for ventricular arrhythmias and sudden cardiac death (SCD). Previous
genome-wide association studies (GWAS) of the QT interval have highlighted pathways
regulating cardiac ion channels, calcium signaling and myocyte internal structure.
However, a large proportion of the heritability remains unexplained, suggesting additional
mechanisms remain undiscovered.
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