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HF-564-02 LONG-TERM OUTCOMES OF TACHYCARDIA INDUCED CARDIOMYOPATHY COMPARED WITH IDIOPATHIC DILATED CARDIOMYOPATHY

      Background

      Tachycardia induced cardiomyopathy (TIC) is a reversible dilated cardiomyopathy (DCM). Data on natural course and prognosis of TIC and comparison with other dilated cardiomyopathies is scarce.

      Objective

      To compare the clinical presentation, comorbidities and long-term outcome of TIC patients with idiopathic DCM patients.

      Methods

      A single center, retrospective cohort study of patients hospitalized with new onset TIC or IDCM between 2007-2017. The primary end point was composite of death, myocardial infarction, thromboembolic events, assist device or heart transplantation and malignant arrhythmia. The secondary end point was recurrent hospitalization due to worsening heart failure (HF) during follow up. Study end points were evaluated for 5 years and for the whole length of follow up.

      Results

      64 TIC and 66 idiopathic DCM (IDCM) patients were enrolled. The primary composite endpoint and all-cause mortality were similar between TIC and IDCM during median follow-up time of ∼6 years (36% vs 29% and 22% vs 15%, respectively). A Kaplan-Meier survival analysis showed no significant difference between TIC and IDCM groups for event-free survival of the composite endpoint (Log Rank, p=0.328) and for all-cause mortality (Log Rank, p=0.139). Recurrent admission occurred earlier in TIC patients compared with IDCM patients (Log Rank, p=0.035) and the risk for HF readmission was significantly higher in TIC (HR: 1.81; 95% CI 1.03-3.18). This risk became insignificant after adjustment to comorbidities (HR: 1.55; 95% CI 0.85-2.8). Nonetheless, the incidence of recurrent hospitalization during the follow-up period was significantly higher in TIC patients (incidence rate ratio 1.59, 95% CI 1.12-2.24; p=0.009).