Catheter ablation is a well-established interventional approach for treating symptomatic
drug-refractory paroxysmal atrial filtration (AF) with a class I, level A guideline.
1
Conventional thermal-based methods, radiofrequency ablation (RFA) and cryoablation,
irreversibly damage the myocardium from protein denaturation and tissue coagulation
to obtain durable ablation and are associated with complications that facilitate the
development of a new methodology of nonthermal AF ablation.To read this article in full you will need to make a payment
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References
- HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation.Heart Rhythm. 2017; 14: e275-e444
- Cryoablation vs. radiofrequency ablation for treatment of paroxysmal atrial fibrillation: a systematic review and meta-analysis.Europace. 2017; 19: 784-794
- Worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation.Circulation. 2005; 111: 1100-1105
- Atrio-esophageal fistula as a complication of precutaneous transcatheter ablation of atrial fibrillation.Circulation. 2004; 109: 2724-2726
- Pulsed field ablation of paroxysmal atrial fibrillation: 1-year outcomes of IMPULSE, PEFCAT, and PEFCAT II.J Am Coll Cardiol Clin Electrophysiol. 2021; 7: 614-627
- Therapeutic perspectives of in vivo cell electropermeabilization.Bioelectrochemistry. 2001; 53: 1-10
- Pulsed field ablation vs. radiofrequency ablation: esophageal injury in a novel porcine model.Circ Arrhythm Eelectrophysiol. 2020; 13e008303
- Ultra-microhistological study of nonthermal irreversible electroporation on the esophagus.Heart Rhythm. 2023; 20: 343-351
Article info
Publication history
Published online: December 01, 2022
Footnotes
Funding Sources: The author has no funding sources to disclose.
Disclosures: The author has no conflicts of interest to disclose.
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© 2022 Heart Rhythm Society. All rights reserved.
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- Ultra-microhistological study of nonthermal irreversible electroporation on the esophagusHeart RhythmVol. 20Issue 3
- PreviewEsophageal ulceration and even fistula are severe complications of pulmonary vein isolation using traditional thermal ablation. Nonthermal irreversible electroporation (NTIRE) is a new technique for pulmonary vein isolation in patients with atrial fibrillation. NTIRE has been shown to be a safe method for pulsed electroporation near the esophagus. NTIRE preserves the structural framework of the esophagus and allows for rapid recovery of the whole layers of the esophagus.
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