EP News: Basic and Translational

  • Nipavan Chiamvimonvat
    Address reprint requests and correspondence: Dr Nipavan Chiamvimonvat, Department of Internal Medicine and Pharmacology, University of California, Davis, GBSF 6315, 451 Health Science Dr, Davis, CA 95616.
    Department of Internal Medicine and Pharmacology, University of California, Davis, Davis, California
    Search for articles by this author
Published:February 08, 2023DOI:
      Bhattacharyya et al (J Clin Invest 2023;133:e153635, PMID 36454649) globally profiled the mouse cardiac conduction system (CCS) cis-regulatory landscape by genetically tagged CCS component-specific nuclei for comprehensive assay for transposase-accessible chromatin-sequencing (ATAC-Seq) analysis. A global CCS-enriched cis-regulatory element (CRE) database, referred to as CCS-ATAC, was established as a key resource for studying CCS-wide and component-specific regulatory functions. Using transcription factor (TF) motifs to construct CCS component-specific gene regulatory networks, the authors identified and independently confirmed several specific TF subnetworks. Furthermore, CCS-ATAC was used to improve the annotation of existing human variants related to cardiac rhythm and nominated a potential enhancer-target pair that was dysregulated by a specific single nucleotide polymorphism. The authors conclude that the established CCS-regulatory compendium identified novel CCS enhancer elements and illuminated potential functional associations between human genomic variants and CCS component-specific CREs.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Heart Rhythm
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect