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Polygenic risk scores are associated with atrial electrophysiologic substrate abnormalities and outcomes after atrial fibrillation catheter ablation

Published:February 16, 2023DOI:https://doi.org/10.1016/j.hrthm.2023.02.011

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      References

        • Gladding P.A.
        • Legget M.
        • Fatkin D.
        • et al.
        Polygenic risk scores in coronary artery disease and atrial fibrillation.
        Heart Lung Circ. 2020; 29: 634-640
        • McCarthy M.I.
        • Abecasis G.R.
        • Cardon L.R.
        • et al.
        Genome-wide association studies for complex traits: consensus, uncertainty and challenges.
        Nat Rev Genet. 2008; 9: 356-369
        • Tam V.
        • Patel N.
        • Turcotte M.
        • et al.
        Benefits and limitations of genome-wide association studies.
        Nat Rev Genet. 2019; 20: 467-484
        • Ellinor P.T.
        • Lunetta K.L.
        • Albert C.M.
        • et al.
        Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
        Nat Genet. 2012; 44: 670-675
        • Kertai M.D.
        • Mosley J.D.
        • He J.
        • et al.
        Predictive accuracy of a polygenic risk score for postoperative atrial fibrillation after cardiac surgery.
        Circ Genom Precis Med. 2021; 14e003269
        • Neumann J.T.
        • Riaz M.
        • Bakshi A.
        • et al.
        Prognostic value of a polygenic risk score for coronary heart disease in individuals aged 70 years and older.
        Circ Genom Precis Med. 2022; 15e003429
        • Weng L.C.
        • Preis S.R.
        • Hulme O.L.
        • et al.
        Genetic predisposition, clinical risk factor burden, and lifetime risk of atrial fibrillation.
        Circulation. 2018; 137: 1027-1038
        • Christophersen I.E.
        • Rienstra M.
        • Roselli C.
        • et al.
        Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
        Nat Genet. 2017; 49: 946-952
        • Khera A.V.
        • Chaffin M.
        • Aragam K.G.
        • et al.
        Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.
        Nat Genet. 2018; 50: 1219-1224
        • Lubitz S.A.
        • Yin X.
        • Lin H.J.
        • et al.
        Genetic risk prediction of atrial fibrillation.
        Circulation. 2017; 135: 1311-1320
        • McNeil J.J.
        • Nelson M.R.
        • Woods R.L.
        • et al.
        Effect of aspirin on all-cause mortality in the healthy elderly.
        N Engl J Med. 2018; 379: 1519-1528
        • Lacaze P.
        • Sebra R.
        • Riaz M.
        • et al.
        Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals.
        Genet Med. 2020; 22: 1883-1886
        • Wong G.R.
        • Nalliah C.J.
        • Lee G.
        • et al.
        Dynamic atrial substrate during high-density mapping of paroxysmal and persistent AF: implications for substrate ablation.
        JACC Clin Electrophysiol. 2019; 5: 1265-1277
        • Wong G.R.
        • Nalliah C.J.
        • Lee G.
        • et al.
        Sex-related differences in atrial remodeling in patients with atrial fibrillation: relationship to ablation outcomes.
        Circ Arrhythm Electrophysiol. 2022; 15e009925
        • Shoemaker M.B.
        • Husser D.
        • Roselli C.
        • et al.
        Genetic susceptibility for atrial fibrillation in patients undergoing atrial fibrillation ablation.
        Circ Arrhythm Electrophysiol. 2020; 13e007676
        • Heida A.
        • van der Does W.F.B.
        • van Staveren L.N.
        • et al.
        Conduction heterogeneity: impact of underlying heart disease and atrial fibrillation.
        JACC Clin Electrophysiol. 2020; 6: 1844-1854
        • Polontchouk L.
        • Haefliger J.A.
        • Ebelt B.
        • et al.
        Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria.
        J Am Coll Cardiol. 2001; 38: 883-891
        • Wong G.R.
        • Nalliah C.J.
        • Lee G.
        • et al.
        Genetic susceptibility to atrial fibrillation is associated with atrial electrical remodeling and adverse post-ablation outcome.
        JACC Clin Electrophysiol. 2020; 6: 1509-1521
        • Giorgios T.
        • Antonio F.
        • Limite L.R.
        • et al.
        Bi-atrial characterization of the electrical substrate in patients with atrial fibrillation.
        Pacing Clin Electrophysiol. 2022; 45: 752-760
        • Parvez B.
        • Shoemaker M.B.
        • Muhammad R.
        • et al.
        Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion.
        Heart Rhythm. 2013; 10: 849-855
        • Vogel S.
        • Rudaka I.
        • Rots D.
        • et al.
        A higher polygenic risk score is associated with a higher recurrence rate of atrial fibrillation in direct current cardioversion-treated patients.
        Medicina (Kaunas). 2021; 57: 1263
        • Choe W.S.
        • Kang J.H.
        • Choi E.K.
        • et al.
        A genetic risk score for atrial fibrillation predicts the response to catheter ablation.
        Korean Circ J. 2019; 49: 338-349