Zeitler et al (J Am Heart Assoc 2023;12:e027871, PMID 36688367) evaluated prespecified
sex-related outcomes for ablation vs drug therapy in the CABANA trial. Symptoms were
assessed over 60 months with the Mayo Atrial Fibrillation (AF)-Specific Symptom Inventory
(MAFSI) frequency score, and quality of life (QOL) was assessed with the Atrial Fibrillation
Effect on Quality of Life (AFEQT) summary and component scores. Women had lower baseline
QOL scores than did men (mean AFEQT scores 55.9 and 65.6, respectively). Patients
who had undergone ablation improved more than patients receiving drug therapy with
similar treatment effect by sex: AFEQT 12-month mean adjusted treatment difference
was 6.1 points for women and 4.9 points for men. Participants with baseline AFEQT
summary scores <70 had greater QOL improvement, with a mean treatment difference at
12 months of 7.6 points for women and 6.4 points for men. The mean difference in MAFSI
frequency score between women randomized to ablation vs drug therapy at 12 months
was −2.5; for men, the difference was −1.3. The authors conclude that ablation resulted in more QOL improvement in both sexes,
driven by improvements in those with lower baseline QOL. Ablation did not eliminate
the AF-related QOL gap between women and men.
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Publication history
Published online: March 06, 2023
Publication stage
In Press Journal Pre-ProofFootnotes
Funding Sources: The author has no funding sources to disclose.
Disclosures: The author has no conflicts of interest to disclose.
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