- Repolarization gradients can provide the substrate for reentry. Limitations have been reported in clinical identification of abnormal substrates using electrocardiographic techniques.
- Ablative pulmonary vein isolation (PVI) is ineffective in atrial fibrillation (AF) prevention in 40% of AF patients. The role of the atrial-pulmonary vein (A-PV) junction in arrhythmogenesis is poorly understood since incomplete PVI can be curative. We aimed to test the hypothesis that the A-PV junction constitutes a structural and functional arrhythmogenic substrate.
- Atrial and pulmonary vein (PV) stretch is proarrhythmic, but the mechanical effect of PV ablation scar on atrial fibrillation (AF) arrhythmogenesis is unknown. We hypothesize that discontinuous PV ablation scars are proarrhythmic because they create heterogeneous stretch.