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CES Abstracts 2021
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- Abstract
B-PO02-021 INCREASED MICROTUBULE DETYROSINATION ENHANCES MECHANO-ARRHYTHMOGENICITY THROUGH TRPA1 IN VENTRICULAR MYOCYTES
Heart RhythmVol. 18Issue 8SupplementS103–S104Published in issue: August, 2021- Breanne Ashleigh Cameron
- Jessi J. Bak
- Matthew R. Stoyek
- T. Alexander Quinn
Cited in Scopus: 0In hypertension, there is an increased risk of sudden cardiac death, which is associated with acute hemodynamic fluctuations in the presence of ventricular structural remodelling. Increased microtubule network (MTN) density (via polymerisation) or stability (via post-translational modifications, such as detyrosination or acetylation) may enhance mechano-transduction in this setting and increase the incidence of mechanically-triggered arrhythmias (‘mechano-arrhythmogenicity’) mediated by TRPA1.
