CES Abstracts 2021
B-YIA2-01 MECHANO-ARRHYTHMOGENICITY IS ENHANCED IN LATE REPOLARISATION DURING ISCHEMIA AND DRIVEN BY A TRPA1-, CALCIUM-, AND REACTIVE OXYGEN SPECIES-DEPENDENT MECHANISMCardiac dyskinesis during ischemia results in arrhythmias via mechanically-induced changes in electrophysiology (‘mechano-arrhythmogenicity’). While cellular mechanisms of mechano-arrhythmogenicity are unknown, ischemic alterations in voltage-Ca2+ dynamics may create a vulnerable period (VP) for mechano-arrhythmogenicity during late repolarisation.
B-PO02-021 INCREASED MICROTUBULE DETYROSINATION ENHANCES MECHANO-ARRHYTHMOGENICITY THROUGH TRPA1 IN VENTRICULAR MYOCYTESIn hypertension, there is an increased risk of sudden cardiac death, which is associated with acute hemodynamic fluctuations in the presence of ventricular structural remodelling. Increased microtubule network (MTN) density (via polymerisation) or stability (via post-translational modifications, such as detyrosination or acetylation) may enhance mechano-transduction in this setting and increase the incidence of mechanically-triggered arrhythmias (‘mechano-arrhythmogenicity’) mediated by TRPA1.