CES Abstracts 2021
B-PO05-010 REMOVING THE VENTRICULAR FAR FIELD FROM UNIPOLAR ATRIAL ELECTROGRAMS IN A CLINICALLY FEASIBLE SETUP WITH A PHYSICALLY MOTIVATED MODEL YIELDS HIGH QUALITY RESULTS
While bipolar electrograms have dominated electrophysiological studies of the atria in the past, unipolar electrograms come with advantages in undistorted morphology but pose undesirable interference with the ventricular far field (VFF). Blanking or template building are common approaches to alleviate this drawback but tremendously reduce data or prolong the procedure. None of the approaches is clinically satisfactory.B-PO05-019 THE ATRIAL-PULMONARY VEIN JUNCTION CONSTITUTES AN ARRHYTHMOGENIC SUBSTRATE
Ablative pulmonary vein isolation (PVI) is ineffective in atrial fibrillation (AF) prevention in 40% of AF patients. The role of the atrial-pulmonary vein (A-PV) junction in arrhythmogenesis is poorly understood since incomplete PVI can be curative. We aimed to test the hypothesis that the A-PV junction constitutes a structural and functional arrhythmogenic substrate.B-011-02 KIR2.1 CHANNELS IN A NOVEL SARCOPLASMIC RETICULUM MICRODOMAIN CONTROL INTRACELLULAR CA2+ DYNAMICS
The strong inward rectifier K+ channel, Kir2.1, is known to localize at the sarcolemma to control the resting potential and the final phase of ventricular repolarization. K+ channels have been suggested to contribute countercurrent to calcium flux across the sarcoplasmic reticulum (SR) membrane, but their identity and function remain controversial.B-011-03 SGK1 DEFICIENCY IS PROTECTIVE IN A MODEL OF SEPSIS-RELATED ATRIAL FIBRILLATION
Sepsis is associated with new onset atrial fibrillation (AF), and AF in septic patients is associated with worse outcomes. Serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase in the PI-3 kinase pathway, is involved in cardiac inflammation. Prior work has suggested a potential therapeutic role for SGK1 inhibition in cardiac arrhythmias, which we investigated in a model of bacterial sepsis-induced AF.B-011-04 ABLATION SCAR IN A SINGLE PULMONARY VEIN CAUSES PROARRHYTHMIC MECHANICAL DESTABILIZATION IN HEALTHY SHEEP ATRIA
Atrial and pulmonary vein (PV) stretch is proarrhythmic, but the mechanical effect of PV ablation scar on atrial fibrillation (AF) arrhythmogenesis is unknown. We hypothesize that discontinuous PV ablation scars are proarrhythmic because they create heterogeneous stretch.B-011-05 PANORAMIC OPTICAL MAPPING AND MICRO COMPUTED TOMOGRAPHY FOR IN-DEPTH 3D CHARACTERIZATION OF THE ARRHYTHMOGENIC SUBSTRATE IN MURINE HEARTS
Optical mapping of murine hearts is currently limited to the epicardium. Action potential duration (APD) heterogeneity is a key driver for initiation and persistence of reentry. When combined with micro CT, optical mapping can provide data on anatomical alterations and structural remodeling contributing to arrhythmogenesis.B-011-06 USING MACHINE LEARNING TO IDENTIFY PATIENTS LIKELY TO REQUIRE REPEAT CATHETER ABLATION FOR ATRIAL FIBRILLATION: INSIGHTS FROM THE UC SAN DIEGO AF ABLATION REGISTRY
Catheter ablation is superior to pharmacologic therapy in maintaining normal sinus rhythm in select patients with atrial fibrillation (AF). However, this procedure is not without risks, and many often require a repeat ablation.B-011-20 EVALUATION OF THE 3-DIMENSIONAL SUBSTRATE OF VENTRICULAR TACHYCARDIA IN A LANGENDORFF PERFUSED HUMAN HEART
The underlying mechanisms of ventricular tachycardia (VT) are not well understood. Most models for VT propagation are based on animal studies or single surface recordings which have limited utility. Human based investigations of VT are often limited by hemodynamic collapse and lack viable ways to assess the myocardial electrical propagation.B-011-21 CARDIAC MAGNETIC RESONANCE PREDICTORS OF VENTRICULAR TACHYCARDIA RECURRENCE AFTER SUBSTRATE BASED ABLATION
Ventricular tachycardia (VT) substrate-based ablation has become increasingly important in patients with structural heart disease-related VT.B-011-22 MACHINE LEARNING TO PREDICT RECURRENT EVENTS FOLLOWING UNEXPLAINED CARDIAC ARREST
Patients who suffer an unexplained cardiac arrest (UCA) are at risk for recurrence.B-011-23 QRS CHARACTERISTICS DURING LEFT BUNDLE BRANCH PACING WITH AND WITHOUT BIDIRECTIONAL LEFT INTRAHISIAN BLOCK
LBB (left bundle branch) pacing has been proposed as a novel modality to achieve cardiac resynchronization. However, selective capture of the left bundle is physiologically expected to produce a wide QRS, with variability based on the integrity of retrograde right bundle conduction.
