Although pulmonary vein (PV) isolation (PVI) has been considered an effective treatment for paroxysmal atrial fibrillation (AF), non-paroxysmal AF is a complex arrhythmia for which no ablation strategy has been demonstrated to be effective and widely accepted. As such, a success rate of ∼55% in these patients with AF (Substrate and Trigger Ablation for Reduction of Atrial Fibrillation Trial Part II [Star AF II trial]) is not acceptable in our opinion and efforts should be made to seek for alternative strategies.