- The arrhythmogenicity of the vein of Marshall (VoM) in atrial fibrillation (AF) has been known for more than 20 years.1 A recent randomized trial showed a reduced odds ratio (0.63; 95% confidence interval 0.41–0.97; P = .04) for the primary outcome of AF or atrial tachycardia (AT) recurrence in patients with persistent AF by adding VoM ethanol infusion (VoM-Et) to the standard ablation approach.2 The VoM is involved in 30% of ATs after AF ablation, and VoM ablation significantly improves the freedom from recurrent arrhythmia.
- Atrial fibrillation (AF) is a particularly complex arrhythmia because the mechanisms leading to fibrillation are not fully understood. Accordingly, ablation strategies have evolved largely on an empirical basis. The creation of linear lesions is a fundamental strategy that is indispensable to an electrophysiology laboratory performing ablation for treatment of this arrhythmia.
- Curative catheter ablation of atrial fibrillation (AF) began with the recognition of ectopic impulses triggering AF, originating dominantly from the pulmonary veins (PV). Electrical isolation of the PV from the LA was proposed to eliminate these triggers from the PV and is now performed with the aid of a circumferential PV mapping (lasso) catheter. In addition to the initiating role of the PV, this structure is also critical as a substrate maintaining AF.1 The importance of PV isolation in AF ablative therapy therefore remains unchanged since the development of this technique whether it is for paroxysmal, persistent or permanent AF.